Diphenhydramine

Product Introduction

CAS:58-73-1

Molecular formula: C17H21NO

Molecular weight:255.35

EINECS NO.:200-396-7

Melting Point:167-172°C

Boiling Point:bp2.0 150-165°C

Density:0.9889 (rough estimate)

Product Description

Diphenhydramine, an antihistamine. It has the effect of antihistamine H1 receptor, has a strong inhibitory effect on the central nervous system, and has atropine-like effect. It is suitable for allergic diseases of skin and mucous membranes, such as urticaria, hay fever, allergic rhinitis, etc. It can also be used to prevent motion sickness such as seasickness, motion sickness, and plane sickness. Drowsiness and dry mouth are the main adverse reactions.

Application

1. Allergies to the skin and mucous membranes, such as urticaria, angioedema, allergic rhinitis, other skin pruritus, anal pruritus, genital pruritus, drug eruption or jaundice, it is also effective for insect bites and contact dermatitis ;
2. Acute allergic reaction, which can reduce the allergic reaction caused by blood transfusion or plasma; antihistamine drugs such as diphenhydramine are often used before blood transfusion, usually 40 mg of diphenhydramine is given intramuscularly, and attention is paid to the screening of blood donors , try not to use blood donors with a history of allergies. Avoid repeated transfusion of the blood of the same donor to avoid antigen-antibody reaction. If there is anti-IgA antibody in the blood recipient, the washed red blood cells can be transfused. This washing method can remove the IgA in the blood of the donor. to prevent allergic reactions.
3. The prevention and treatment of motion sickness and seasickness has a strong antiemetic effect, and can also be used to prevent and treat radiation sickness, vomiting after surgery, and nausea and vomiting caused by drugs;
4. For Parkinson's disease and extrapyramidal symptoms;
5. Sedation, used for hypnosis and preoperative administration;
6. Dental local anesthesia. When the patient is highly allergic to commonly used local anesthetics, 1% diphenhydramine solution can be used as a dental local anesthetic;
7. Antitussive, as a non-addictive cough medicine, it is suitable for treating cough caused by cold or allergy, but its antitussive effect has not been confirmed.