DIRECT BLUE 15 NEW

• MOLECULAR FORMULA :

• C34-H24-N6-O16-S4.4Na

• MOLECULAR WEIGHT :

• 992.84

• WISWESSER LINE NOTATION :

• L66J BQ DSWO HSWO JZ CNUNR CO1 DR BO1 DNUN- CL66J BQ DSWO HSWO JZ &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 52500 mg/kg/14D-C

• TOXIC EFFECTS :

• Liver - other changes Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 10 gm/kg/13W

• TOXIC EFFECTS :

• Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 168 gm/kg/96W-C

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Brain and Coverings - tumors Blood - leukemia

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Intraperitoneal

• DOSE :

• 70 mg/kg

• SEX/DURATION :

• female 8 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Intraperitoneal

• DOSE :

• 200 mg/kg

• SEX/DURATION :

• female 8 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Intraperitoneal

• DOSE :

• 140 mg/kg

• SEX/DURATION :

• female 8 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Effects on Embryo or Fetus - other effects to embryo

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 5 gm/kg

• SEX/DURATION :

• female 8-12 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Effects on Newborn - other postnatal measures or effects

MUTATION DATA

• TYPE OF TEST :

• Mutation in microorganisms

• TEST SYSTEM :

• Bacteria - Salmonella typhimurium

• DOSE/DURATION :

• 100 ug/plate

• REFERENCE :

• JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 18,111,1986 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,235,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,235,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,235,1993 TOXICOLOGY REVIEW ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 1,131,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4514 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 69 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4514 No. of Facilities: 485 (estimated) No. of Industries: 7 No. of Occupations: 7 No. of Employees: 4527 (estimated) No. of Female Employees: 201 (estimated)