Dithiocyano methane NEW

• DATA ITEMS CITED :

• 17

• MOLECULAR FORMULA :

• C3-H2-N2-S2

• MOLECULAR WEIGHT :

• 130.19

• WISWESSER LINE NOTATION :

• NCS1SCN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 55 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• REFERENCE :

• DIMCAL Developments in Industrial Microbiology. (Soc. for Industrial Microbiology, 1401 Wilson Blvd., Arlington, VA 22209) V.1- 1960- Volume(issue)/page/year: 12,404,1971

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 3600 ug/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• REFERENCE :

• CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03787

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Administration onto the skin

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 398 mg/kg

• TOXIC EFFECTS :

• Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Liver - other changes

• REFERENCE :

• NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0545751

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 20 mg/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Vascular - BP lowering not characterized in autonomic section

• REFERENCE :

• AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 150,257,1930 ** OTHER MULTIPLE DOSE TOXICITY DATA **

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 240 mg/kg/2W-I

• TOXIC EFFECTS :

• Gastrointestinal - necrotic changes Endocrine - changes in thymus weight Related to Chronic Data - death

• REFERENCE :

• NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-94-3381

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 520 mg/kg/13W-I

• TOXIC EFFECTS :

• Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Blood - changes in erythrocyte (RBC) count Biochemical - Metabolism (Intermediary) - other proteins

• REFERENCE :

• NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-94-3381

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 120 mg/kg/2W-I

• TOXIC EFFECTS :

• Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight

• REFERENCE :

• NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-94-3381

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 520 mg/kg/13W-I

• TOXIC EFFECTS :

• Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Gastrointestinal - other changes Liver - other changes

• REFERENCE :

• NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-94-3381 ** REPRODUCTIVE DATA **

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 260 mg/kg

• SEX/DURATION :

• male 13 week(s) pre-mating

• TOXIC EFFECTS :

• Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

• REFERENCE :

• NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-94-3381 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81675 No. of Facilities: 159 (estimated) No. of Industries: 8 No. of Occupations: 3 No. of Employees: 1670 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81675 No. of Facilities: 1056 (estimated) No. of Industries: 26 No. of Occupations: 24 No. of Employees: 24231 (estimated) No. of Female Employees: 995 (estimated)