Eleclazine hydrochloride NEW
| Price | $56 | $118 | $178 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Eleclazine hydrochloride | CAS No.: 1448754-43-5 |
| Purity: 99.86% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Eleclazine hydrochloride |
| Description | Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM). |
| In vitro | Inhibition by GS-6615 of ATX-II enhanced late INa is potently correlated with shortening of myocyte APD and isolated heart MAPD[1]. Eleclazine hydrochloride inhibits ATX-II enhanced late INa in ventricular myocytes, shorten the ATX-II induced prolongation of APD, MAPD, QT interval. It also decreased spatiotemporal dispersion of repolarization and ventricular arrhythmias. Selective inhibition of cardiac late INa with eleclazine hydrochloride confers dual protection against vulnerability to ischemia-induced AF. That decreases atrial and ventricular repolarization abnormalities before and during adrenergic stimulation without negative inotropic effects. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 100 mg/mL (221.32 mM) |
| Keywords | Inhibitor | Eleclazine | GS-6615 | GS6615 | porcine | Eleclazine Hydrochloride | Sodium Channel | KcsA | Eleclazine hydrochloride | Na+ channels | inhibit | Na channels | epinephrine | Potassium Channel | GS6615 Hydrochloride | GS 6615 Hydrochloride | hiPSC | atrial premature beats | GS 6615 | GS-6615 Hydrochloride | cardiac arrhythmias |
| Inhibitors Related | Phenytoin sodium | Lidocaine Hydrochloride hydrate | Lidocaine | Valproic Acid | Butamben | Lidocaine hydrochloride | L-Aspartic aicd sodium | Mebeverine hydrochloride | Amitriptyline hydrochloride | Riluzole | Benzocaine | Nefopam hydrochloride |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
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