ER-27319 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: ER-27319 | CAS No.: 201010-95-9 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | ER-27319 |
| Description | ER-27319, an acridone derivative, serves as a potent and selective inhibitor of spleen tyrosine kinase (SYK), effectively impeding both the tyrosine phosphorylation and enzymatic activity of SYK. With an inhibitory concentration (IC50) of 10 µM, this compound suppresses the release of allergic mediators from human and rat mast cells triggered by antigens, making it useful for allergy research [1] [2]. |
| In vitro | ER-27319 (24 h) inhibits antigen-induced myo-inositol phosphate generation, arachidonic acid release, and histamine and tumor necrosis factor α secretion in RBL-2H3 cells, rat peritoneal, and human cultured mast cells, with an IC50 value of approximately 10 μM [1]. ER-27319 (10-30 μM, 10 min) selectively inhibits the tyrosine phosphorylation of SYK induced by immunoreceptor tyrosine activation motif upon FcεRI γ phosphorylation [1]. ER-27319 (up to 100 μM, 60 min) does not inhibit ZAP-70 tyrosine phosphorylation triggered by CD3 stimulation in Jurkat cells [1]. ER-27319 (100 μM, 10 min) suppresses the tyrosine phosphorylation of two proteins (38, 70 kD) and reduces the tyrosine phosphorylation of two other proteins (62, 80 kD) in canine cutaneous mastocytoma cells challenged with anti-IgG [2]. |
| Storage | Shipping with blue ice. |
| Inhibitors Related | Fostamatinib | R112 | Syk-IN-3 | Ellagic acid | Piceatannol | Cerdulatinib | PRT062607 hydrochloride | Fostamatinib Disodium | ANTHRAQUINONE-2-CARBOXYLIC ACID | GSK1904529A | Cerdulatinib hydrochloride | R406 free base |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $493.00/10mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-10-23 | |
| $0.00/25Kg/Drum |
VIP6Y
|
Jinan Finer Chemical Co., Ltd
|
2019-10-24 | |
| $10.00/1kg |
VIP1Y
|
Hebei Zhuanglai Chemical Trading Co Ltd
|
2024-12-03 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
INQUIRY