Product Details
| Product Name:
Esonarimod |
CAS No.:
101973-77-7 |
| Purity:
99.83% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Esonarimod |
| Description | Esonarimod (KE-298) is an antirheumatic drug designed to alleviate symptoms associated with rheumatoid arthritis. |
| Cell Research | For in vitro experiment, Esonarimod (KE-298) is dissolved in ethanol and diluted with culture medium or distilled water.RAW264.7 cells are used in this study. For NO production, RAW264.7 cells [2×105/0.2 mL of RPMI-1640 supplemented by 10% heat inactivated fetal bovine serum (FBS), penicillin G (100 U/mL), and streptomycin (100 μg/mL)] are stimulated with 100 ng/mL of Escherichia coli 026:B6 lipopolysaccharide in the presence of Esonarimod (KE-298) (0, 10, 30, 100, 200, 300 μg/mL) in 96 well plates and incubated 24 h at 37°C in an atmosphere of 5% CO2 in air. After incubation, the supernatants are collected and assayed for nitrite (NO2-) instead of NO[1]. |
| Kinase Assay | To test enzyme activity of NOS, the lysate from RAW264.7 cells (a protein concentration of 37.5 μg/200 μL) is incubated for 3 h at 37°C with 100 mM of L-arginine in the presence of Esonarimod (KE-298) and the conversion of L-arginine to nitrite is monitored. |
| Animal Research | Seven-week-old male Wistar rats is administered Esonarimod (5 mg/kg once daily) orally by gastric intubation. |
| In vitro | The IC50 of Esonarimod is 117.5 μg/mL. In RAW264.7 cells, Esonarimod (KE-298) (10 to 300 μg/mL) suppresses the production of NO in a dose-dependent manner. |
| In vivo | After repeated oral administration of Esonarimod (14C-KE-298), the radioactivity rapidly decreases with no accumulation observed. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (214.03 mM)
|
| Keywords | KE298 | inhibit | Esonarimod | Inhibitor | KE 298 |
| Inhibitors Related | Inosine pranobex | Apilimod mesylate | Amlexanox | Isosteviol | Dexamethasone acetate | L-Arginine | Bergenin | α-Terpineol | Dexamethasone | Diallyl disulfide | Linalool | Apilimod |
| Related Compound Libraries | Bioactive Compound Library | Cytokine Inhibitor Library | ReFRAME Related Library | HIF-1 Signaling Pathway Compound Library | Drug Repurposing Compound Library | NO PAINS Compound Library | Anti-Aging Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| Product name |
Price |
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Suppliers |
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$1.00/1g |
VIP5Y
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Career Henan Chemical Co
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2019-12-25 |
United States