Product Details
| Product Name:
Ex26 |
CAS No.:
1233332-37-0 |
| Purity:
99.62% |
Supply Ability:
10g |
| Release date:
2024/11/17 |
Product Introduction
Bioactivity
| 名称 | Ex26 |
| 描述 | Ex26 (S1P1-IN-Ex26) is a selective and potent sphingosine 1-phosphate receptor 1 (S1P1) antagonist that disrupts SR-B1-S1PR1 interactions and inhibits S1P-S1PR1 signaling. Ex26 is used in experimental autoimmune encephalomyelitis, atherosclerosis, and gastric cancer. |
| 体外活性 | In U2OS cells and Chinese hamster ovary cells, Ex26 (0-10 μM; 1 hour) was confirmed as a potent and selective antagonist of S1P1 (IC50=0.93 nM)[1]. |
| 体内活性 | In eight-week-old male C57Bl/6J mice, S1P1-IN-Ex26 (3 mg/kg; intraperitoneal injection; once daily; 3 days) induced lymphocyte sequestration at low doses, with an ED50 of 0.06 mg/kg after 2 hours of treatment. This led to significant retention of T and B cells within the lymph nodes and significant decreases in T and B cells within the spleen[1]. |
| 存储条件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 关键字 | S1P1INEx26 | S1P1 IN Ex26 | S-1P1-IN-Ex26 |
| 相关产品 | Fingolimod hydrochloride | SLP9101555 | SKI-178 | LX-2931 | K145 hydrochloride | ASP-4058 | Ceranib-2 | Siponimod | MP-A08 | Ozanimod |
| 相关库 | 经典已知活性库 | 已知活性化合物库 | GPCR靶点分子库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States