Product Details
| Product Name:
G43 |
CAS No.:
690693-02-8 |
| Purity:
99.21% |
Supply Ability:
10g |
| Release date:
2024/11/16 |
Product Introduction
Bioactivity
| 名称 | G43 |
| 描述 | G43 is a potent and selective glucosyltransferase inhibitor that inhibits GtfB and GtfC with Kd values of 3.7 μM and 46.9 nM, respectively.G43 exhibits in vitro and in vivo anti-Streptococcus mutans activity and can be used for caries studies. |
| 体外活性 | G43 (16 h) inhibits Streptococcus mutans biofilm by 85% at a concentration of 12.5 μM.[1]
G43 (25 μM; 24 h) reduces glucan production by glycosyltransferase (Gtfs) and continuously inhibits the activities of GtfB and GtfC, with an inhibition rate of 80% for both enzymes.[1]
G43 (25 μM; 24 h) has no significant effect on the expression of gtfs (gtfB, gtfC and gtfD) in UA159 mutans Streptococcus mutans.[1]
G43 (50 μM; 24-48 h) reduces biofilm formation by reducing the production of water-insoluble exopolysaccharides in wild-type Streptococcus mutans.[2] |
| 体内活性 | G43 (100 µM; administered topically twice daily for 4 weeks; rat with S. mutans UA159 infected) reduces Streptococcus mutans virulence but did not lose weight over the course of the study. in vivo.[1] |
| 存储条件 | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (131.83 mM)
|
| 关键字 | G43 |
| 相关产品 | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Doxycycline (hyclate) | Kanamycin sulfate | G-418 disulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Dimethyl sulfoxide | Crystal Violet |
| 相关库 | 经典已知活性库 | 抑制剂库 | 已知活性化合物库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/5mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
United States