Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >Biochemical Engineering>Inhibitors>Metabolism>GS-441524
GS-441524
  • GS-441524
  • GS-441524
  • GS-441524
  • GS-441524
  • GS-441524

GS-441524 NEW

Price $30
Package 25KG
Min. Order: 1KG
Supply Ability: 10000kg/per week
Update Time: 2023-08-16

Product Details

Product Name: GS-441524 CAS No.: 1191237-69-0
EC-No.: 200-001-8 Min. Order: 1KG
Purity: 98%~99% Supply Ability: 10000kg/per week
Release date: 2023/08/16


Article illustration

Article illustration


GS-441524 Basic information
Product Name:GS-441524
Synonyms:(2R,3R,4S,5R)-2-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLANE-2-;(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile;2-C-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-2,5-ANHYDRO-3,4-O-(1-METHYLETHYLIDENE)-D-ALTRONONITRI;(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile;D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-;2-C-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-Altrononitrile;GS441525;(2R,3R,4S,5R)-2-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)TETRAHYDRO
CAS:1191237-69-0
MF:C12H13N5O4
MW:291.26
EINECS:200-001-8
Product Categories:GS;API;Intermediates;API;3;1191237-69-0
Mol File:1191237-69-0.mol
GS-441524 Chemical Properties
Melting point > 233° C (dec.)
density 1.84±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (>25 mg/ml)
form solid
pka12.13±0.70(Predicted)
color Off-white
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIInChI=1/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/s3
InChIKeyBRDWIEOJOWJCLU-QHRJDZJMNA-N
SMILESC([C@]1(C2=CC=C3C(=NC=NN23)N)[C@@H]([C@H](O)[C@@H](CO)O1)O)#N |&1:1,12,13,15,r|
CAS DataBase Reference1191237-69-0
DescriptionGS-441524 is the active prodrug of the broad-spectrum antiviral Remdesivir. GS-441524 is an adenosine nucleotide analog in viral RNA production. It is a nucleotide analog inhibitor of RNA-dependent RNA polymerases (RdRps). The compound interferes with the action of viral RNA polymerase and evades proofreading by viral exoribonuclease (ExoN), causing a decrease in viral RNA production (RNA synthesis arrest), either by terminating RNA chains or causing mutations. It inhibits MERS-CoV or SARS-CoV-infected HAE cultures (EC50=74nM and 69nM) and murine hepatitis virus (MHV) (EC50=30nM). In vivo, remdesivir (25 and 50 mg/kg) reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection. Remdesivir is used as a treatment for Ebola virus disease and Marburg virus infections and other single-stranded RNA viruses such as respiratory syncytial virus, Junin virus, Lassa fever virus, Nipah virus, Hendra virus and the coronaviruses (including MERS and SARS viruses). Remdesivir is effective in the control of 2019-nCoV (COVID-19) infection in vitro. It now also has been studied as a potential treatment for SARS-CoV-2 infections.

Article illustration

Article illustration

Article illustration

Article illustration







Company Profile Introduction

Shandong Huisheng Import & Export Co., Ltd. is located in Jinan city, Shandong Province, is a collection of domestic trade, international trade in one of the diversified services company. Our goal is to provide customers with high quality solutions and one-stop purchasing experience. At present, the company business scope involves five areas: Organic chemical raw materials, inorganic chemical raw materials, fine chemical raw materials, dangerous chemicals and green environmental protection chemical technology project promotion, and we has also established good relations of cooperation with several well-known enterprises and won the strong support of extensive trust from the new and old customers. Products are widely used in automobile, household appliances, office supplies, mobile phone accessories, routers, food, medical and other fields. At present, our business covers 30 countries, and our customers mainly come from Australia, New Zealand, Canada, Germany, France, Poland, South Korea, Russia, Bangladesh, Vietnam, Kazakhstan, India, Ghana, Nigeria, South Africa, Egypt and other more than 30 countries. The company has a sound quality management system and advanced professional equipment, with a positive attitude to meet the changing needs of customers. We take "quality products, quality service, competitive price, timely delivery" as the purpose, looking forward to greater cooperation with overseas customers on the basis of mutual benefit. Our company provides a wide range of products to meet your various needs. Since its inception, the company has always adhered to the "quality first, customer first, reputation first" business policy, wholeheartedly meet the potential needs of our customers. Under the irresistible situation of economic globalization, our company is willing to cooperate sincerely with enterprises around the world to achieve a win-win situation.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$20.00/1Box
VIP1Y
Qingdao Xinli Technology Development Co., Ltd.
2024-07-04
$22.00/10vial
VIP1Y
Hebei Anlijie Biotechnology Co., Ltd
2024-05-20
$0.00/25kg
VIP1Y
Hebei Mojin Biotechnology Co.,Ltd
2024-05-17
$18.00/10kg
VIP1Y
Hebei Shengyang Water Conservancy Engineering Co., Ltd.
2024-05-07
$23.00/1Box
VIP1Y
Shanghai Getian Industrial Co., LTD
2024-04-28
$50.00/1kg
VIP1Y
Ouhuang Engineering Materials (Hubei) Co., Ltd
2024-04-26
$1.00/1kits
VIP1Y
Hebei Jingbo New Material Technology Co., Ltd
2024-04-25
$0.00/1Gram
VIP1Y
Hangzhou Hyper Chemicals Limited
2024-04-17
$20.00/1kg
VIP1Y
Shaanxi Franta Biotechnology Co., Ltd
2024-04-01
$20.00/1kg
VIP2Y
Suzhou Sanyi Polymer Chemical Technology Co., Ltd.
2024-03-27
  • Since: 2020-11-16
  • Address: Room 202-9, Building 1, Evergrande Huafu, Dongying Road, Huaiyin District, Jinan City, Shandong Prov
INQUIRY

18963783019
da@zhongda-biotech.com