GW0742
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 50000 |
| Update Time: | 2024-07-15 |
Product Details
| Product Name: GW0742 | CAS No.: 317318-84-6 |
| EC-No.: 206-141-6 | Min. Order: 1g |
| Purity: 99.98% | Supply Ability: 50000 |
| Release date: 2024/07/15 |
CAS No.:317318-84-6
Synonyms:GW 0742;
Formula:C21H17F4NO3S2
Exact Mass:471.05900
Molecular Weight:471.48800
PSA:112.96000
LogP:6.34050
Description:
GW0742 is a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice.
A high throughput screening campaign was conducted to identify small molecules with the ability to inhibit the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator 2. These inhibitors represent novel molecular probes to modulate gene regulation mediated by VDR. The peroxisome proliferator-activated receptor δ (PPARδ) agonist GW0742 was among the identified VDR-coactivator inhibitors and has been characterized herein as a pan nuclear receptor antagonist at concentrations higher than 12.1 µM. The highest antagonist activity for GW0742 was found for VDR and the androgen receptor (AR). Surprisingly, GW0742 behaved as PPAR agonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations. A unique spectroscopic property of GW0742 was identified as well. In the presence of rhodamine-derived molecules, GW0742+ increased fluorescence intensity and fluorescence polarization at an excitation wavelength of 595 nm and emission wavelength of 615 nm in a dose dependent manner. The GW0742-inhibited NR-coactivator binding resulted in a reduced expression of five different NR target genes in LNCaP cells in the presence of agonist. Especially VDR target genes CYP24A1, IGFBP-3 and TRPV6 were negatively regulated by GW0742. GW0742 is the first VDR ligand inhibitor lacking the secosteroid structure of VDR ligand antagonists. Nevertheless, the VDR-meditated downstream process of cell differentiation was antagonized by GW0742 in HL-60 cells that were pretreated with the endogenous VDR agonist 1,25-dihydroxyvitamin D3.
Email:doublewin_bella@foxmail.com
WhatsApp:+86 19971437628
Skype:BELLE1996
Contact me!
Order step:
1: After our quation ,you will choose to accept or not.
2: If you decide to have a try, choose a payment method to pay for the order.
3: We will sent the package out in 24hours after we received the payment ,then will sent the tracking number with packaging detail to you via mai.
4: We will help track the package until you receive it successful,if accident happen ,we will see the reason to decide re-sent for free or half-price re-sent.
Our Competitive Advantages:
1. Rich experience: we specialize in this field for many years, our steroids have been exported almost over the world. Such as USA, Canada, UK, Brazil, Germany, Russia, Australia, Greece, Poland, Bulgaria, Rumania, Netherlands, Sweden, Ukraine, Latvia, Lithuania, Ireland, Austria, Iran, Turkey, Mexico, Thailand, India, Malaysia, Singapore, other Middle East countries, European countries, American countries and more Areas.
2. Great quality: High purity and Favorable price. Good quality is the first base of our success. All of our products enjoys high purity. Thus, it can make sure your demand. Welcome order the samples, MOQ just 10 grams.
3. Safe and fast delivery: Lots of different discreet safe packing methods, experience in choosing express, 4~7 days to arrive, successful rate 99%.
4. Experiential order and cooperation: Besides raw powders, we offer hormone solution and Recipes. We can teach you or discuss how to make hormone solution on the site. Any discussion and question is welcome!
Packaging & Service:
1. Mass stock, to make sure delivery promptly every day when the payment is done.
2. Having been engaged in this field for years, we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.
3. Well-trained and disciplined packing team which is professional enough to provide you a safe package. It also avoid a lot of emergency happen during the delivery so that high customs pass is guaranteed. Unique ways to ship 10grams to 20 kilograms powders(or 100ml to 30 Liter liquids) at one time to your destination.
4. Packing pictures and tacking number are provided within 24 hours as soon as receiving the payment. Updated tracking code will be provided every other day just for you can hold a palm of your package.
5. Perfect after-sale service: Any questions or problems happened after receiving the product.
Please feel free to contact us. 24/7 online to solve your various problems!
| We also Supply | ||
doublewin_bella@foxmail.com | WhatsApp:+86 19971437628 | |
| Oral Products | Oxandrolone (Anavar) | Stanozolol (Winstrol) |
| Oxymetholone (Anadrol) | Dianabol(Methandrostenolone) | |
| Testosterone | Test Base | 17-methyltestostero(methyl testos terone) |
| Test Enanthate | 17α-Methyl-Testos terone | |
| Test Acetate | Oral turinabol(4-Chlorodehydromethyltestosterone) | |
| Test Propionate | Turinabol(Chloroterone Acetate,Clostebol Acetate) | |
| (Test Phenylpropionate) | ||
| Test Isocaproate | Hexadrone | |
| Test Decanoate | Mesterolone(Proviron) | |
| Test Undecanoate | Test Cypionate | |
| 1-Testosterone | Test Sustanon 250 | |
| 1-Testosterone Cypionate | ||
| Nandrolone | Nandrolone | Nandrolone Undecanoate |
| Nandrolone Propionate | Nandrolone Cypiontate | |
| Nandrolone Decanoate(DECA) | Stanolone (DHT) | |
| Nandrolone Phenypropionate | ||
| Mestanolone | ||
| Boldenone | Boldenone base | |
| Boldenone Propionate | ||
| Boldenone Undecylenate(Equipoise) | ||
| Boldenone cypiontate | ||
| Boldenone Acetate | ||
| Trenbolone | Trenbolone base | |
| Trenbolone acetate (Finaplix) | ||
| Trenbolone enanthate (Parabolan) | ||
| Trenbolone hexahydrobenzyl Carbonate | ||
| Ti bolone | ||
| Methylstenbolone | ||
| Methenolone | Drostanolone Propionate (Masteron p) | |
| Methenolone Enanthate | Methenolone Acetate | |
| DH EA | DHEA(Dehydroepiandrosterone) | Epiandrosterone |
| 1-DHEA | Epiandrosterone Acetate | |
| 4-DHEA | ||
| 7-Keto-DH EA | ||
| Others | Methyl dienedione | 2, 4-Dinitrophenol |
| Trendione/Trenavar | Dustasteride | |
| 6-OXO | Des onide | |
| 11-OXO | Tria mcinolone | |
| Epistane/Methyl Epitiostanol | Finasteride | |
| Androstatrienedione | Cytomel, T3 | |
| L-Thyroxine, T4 | ||
| Rimonabant | ||
| L-Carnitine | ||
| Sex Enhancer | Flibanserin | Acetildenafil (Hongdenafil) |
| Cia lis (Tadalafil) | Yohimbine Hcl | |
| Via gra (Silde nafil) Vardenafil (Le vitra) | ||
| Maca Extract | ||
| Pain Killer | Benzocaine / Benzocaine hcl | Tetracaine / Tetracaine HCL |
| Procaine / Procaine Hcl | Bupivacaine/ Bupivacaine HCL | |
| Lidocaine HCL | Articaine / Articaine hcl | |
| Anti-Estrogen | Tamoxifen Citrate (Nolvadex) | Anastrozole (Arimidex) |
| Clomiphene citrate (Clomid) | Letrazole(Femara / For mestane) | |
| Exe mestane(Aromasin) | ||
| Pharmaceuticals | Phe nacetin | Raloxifene HCL |
| Theophylline | ||
| Dexamethasone Sodium Phosphate | Fura zabol THP | |
| Paracetamol | Atorvastatin Calcium | |
| Pregabalin | Lorcaserin | |
| Carbergoline | ||
| Safe Organic Solvents | Gamma-Butyrolactones(GBLsolvents ) | Benzyl Alcohol(BA) |
| 1,4-Butanediol(BDO) | Benzyl benzoate(BB) | |
| Ethyl Oleate(EO) | Guaiacol | |
| Grape Seed Oil(GSO) | Poly Ethylene Glycol(PEG) | |
| Polysorbate 80 | ||
| H G H&Peptides | HGH 176-191 2mg/vial | Ipamorelin 2mg/vial |
| MGF PEG MGF | Hexarelin 2mg/vial | |
| CJC-1295 / with DAC | Sermorelin 2mg/vial | |
| PT-141 10mg/vial | Selank 5mg/vial | |
| MT-1 MT-2 10mg/vial | Follistatin 344 | |
| GHRP-2 5mg/vial & 10mg/vial | Follistatin 315 | |
| GHRP-6 5mg/vial & 10mg/vial | Eptifibatide | |
| SARMs | Aicar | MK-2866/Ostarine/Enobosarm |
| Andarine / S4 | RAD-140 | |
| Andarine / GTX-007 | SR9011 | |
| GW-501516(cardarine) | SR9009 | |
| LGD-4033 | Sunifiram | |
| MK-677/Ibutamoren/Nutrobal | YK11 |
Company Profile Introduction
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $50.00/10g |
VIP1Y
|
hebei hongtan Biotechnology Co., Ltd
|
2024-06-05 | |
| $32.00/1Box |
VIP1Y
|
zhuzhou dingcheng meihei comestic co.,ltd
|
2024-05-29 | |
| $0.00/25kg |
VIP1Y
|
Hebei Mojin Biotechnology Co.,Ltd
|
2024-05-16 | |
| $3.00/1kg |
VIP1Y
|
Shanghai Aosiris new Material Technology Co., LTD
|
2024-04-19 | |
| $5600.00/100kg |
VIP1Y
|
Guangdong Tuoyuan Biotechnology Co., LTD
|
2024-03-27 | |
| $1.00/1g |
VIP4Y
|
Dorne Chemical Technology co. LTD
|
2024-03-26 | |
| $10.00/1kg |
VIP1Y
|
Wuhan Xinhao Biotechnology Co., Ltd
|
2024-02-23 | |
| $30.00/100g |
VIP1Y
|
Sigma Audley
|
2024-01-29 | |
| $0.00/1kg |
VIP1Y
|
Shandong Hanjiang Chemical Co., Ltd
|
2024-01-25 | |
| $30.00/1KG |
VIP1Y
|
Wuhan Ruichi Technology Co., Ltd
|
2024-01-04 |
China