![GW0742](/ProductImageEN/2023-08/Large/efcce7d0-8334-43a9-8c6a-9bb9eaa22620.jpg)
GW0742 NEW
Price | Get Latest Price | ||
Package | 1KG | 5KG | 25KG |
Min. Order: | 1KG |
Supply Ability: | 20 T each week |
Update Time: | 2023-08-23 |
Product Details
Product Name: GW0742 | CAS No.: 317318-84-6 |
EC-No.: 1532714-185-1 | Min. Order: 1KG |
Purity: 98%~99% | Supply Ability: 20 T each week |
Release date: 2023/08/23 |
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Product Name: | GW0742 |
Synonyms: | 2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy);GW 0742X;GW 610742;GWdelta 0742;2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylpheno;GW0742;[4-[[[2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-THIAZOLYL]METHYL]THIO]-2-METHYLPHENOXY]ACETIC ACID;4-[2-(3-FLUORO-4-TRIFLUOROMETHYL-PHENYL)-4-METHYL-THIAZOL-5-YLMETHYLSULFANYL]-2-METHYL-PHENOXY-ACETIC ACID |
CAS: | 317318-84-6 |
MF: | C21H17F4NO3S2 |
MW: | 471.49 |
EINECS: | 1532714-185-1 |
Product Categories: | Inhibitors;Intermediates & Fine Chemicals;All Inhibitors;Pharmaceuticals;Intracellular receptor;Inhibitor;317318-84-6 |
Mol File: | 317318-84-6.mol |
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GW0742 Chemical Properties |
Melting point | 134.5-135.5 °C |
Boiling point | 591.5±60.0 °C(Predicted) |
density | 1.46±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: >5 mg/mL |
form | solid |
pka | 3.17±0.10(Predicted) |
color | white |
InChI | InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28) |
InChIKey | HWVNEWGKWRGSRK-UHFFFAOYSA-N |
SMILES | C(O)(=O)COC1=CC=C(SCC2SC(C3=CC=C(C(F)(F)F)C(F)=C3)=NC=2C)C=C1C |
Safety Information |
WGK Germany | 3 |
HS Code | 38220090 |
MSDS Information |
Provider | Language |
---|---|
SigmaAldrich | English |
GW0742 Usage And Synthesis |
Description | GW0742 is a PPARδ/β agonist very similar in molecular structure to GW501516 (Cardarine) — with the exception of one atom. It is often mentioned in comparison with Cardarine. This drug is mostly used by athletes to improve their stamina. The fat affecting properties of GW0742 also make it a good promoter of energy in the body. Additionally, this drug helps increase the oxidative abilities of your body muscles. |
Chemical Properties | Light Yellow Solid |
Uses | GW0742 is a small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ). It shows an EC50 of 1.1 nM against PPAR δ with 100-fold selectivity over the other human subtypes. |
Definition | ChEBI: GW 0742 is a monocarboxylic acid. |
Biological Activity | GW 0742 is a potent and highly selective PPARδ agonist. EC50 values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes. |
storage | Desiccate at +4°C |
GW0742 Preparation Products And Raw materials |
Raw materials | (2-Bromo-4-methylthiazol-5-yl)methanol |
Company Profile Introduction
Shandong Huisheng Import & Export Co., Ltd. is located in Jinan city, Shandong Province, is a collection of domestic trade, international trade in one of the diversified services company. Our goal is to provide customers with high quality solutions and one-stop purchasing experience. At present, the company business scope involves five areas: Organic chemical raw materials, inorganic chemical raw materials, fine chemical raw materials, dangerous chemicals and green environmental protection chemical technology project promotion, and we has also established good relations of cooperation with several well-known enterprises and won the strong support of extensive trust from the new and old customers.
Products are widely used in automobile, household appliances, office supplies, mobile phone accessories, routers, food, medical and other fields. At present, our business covers 30 countries, and our customers mainly come from Australia, New Zealand, Canada, Germany, France, Poland, South Korea, Russia, Bangladesh, Vietnam, Kazakhstan, India, Ghana, Nigeria, South Africa, Egypt and other more than 30 countries.
The company has a sound quality management system and advanced professional equipment, with a positive attitude to meet the changing needs of customers. We take "quality products, quality service, competitive price, timely delivery" as the purpose, looking forward to greater cooperation with overseas customers on the basis of mutual benefit.
Our company provides a wide range of products to meet your various needs. Since its inception, the company has always adhered to the "quality first, customer first, reputation first" business policy, wholeheartedly meet the potential needs of our customers. Under the irresistible situation of economic globalization, our company is willing to cooperate sincerely with enterprises around the world to achieve a win-win situation.
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- Since: 2020-11-16
- Address: Room 202-9, Building 1, Evergrande Huafu, Dongying Road, Huaiyin District, Jinan City, Shandong Prov
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