Gypenoside L NEW
| Price | $128 | $312 | $397 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-11 |
Product Details
| Product Name: Gypenoside L | CAS No.: 94987-09-4 |
| Purity: 99.65% | Supply Ability: 10g |
| Release date: 2024/11/11 |
Product Introduction
Bioactivity
| 名称 | Gypenoside L |
| 描述 | Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory activity. |
| 体外活性 | gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum, on cancer cell growth.?We found that Gyp-L increased the SA-β-galactosidase activity, promoted the production of senescence-associated secretory cytokines, and inhibited cell proliferation of human liver and esophageal cancer cells.?Moreover, Gyp-L caused cell cycle arrest at S phase, and activated senescence-related cell cycle inhibitor proteins (p21 and p27) and their upstream regulators.?In addition, Gyp-L activated p38 and ERK MAPK pathways and NF-κB pathway to induce senescence.?Consistently, adding chemical inhibitors efficiently counteracted the Gyp-L-mediated senescence, growth inhibition, and cell cycle arrest in cancer cells.?Furthermore, treatment with Gyp-L, enhanced the cytotoxicity of clinic therapeutic drugs, including 5-fluorouracil and cisplatin, on cancer cells.?Overall, these results indicate that Gyp-L inhibits proliferation of cancer cells by inducing senescence and renders cancer cells more sensitive to chemotherapy[1]. |
| 存储条件 | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 166.67 mg/mL (208.07 mM), Sonication is recommended. |
| 关键字 | Gypenoside L | MAPK | Extracellular signal regulated kinases | NF-κB | Nuclear factor-κB | saponin | anti-tumor | Nuclear factor-kappaB | inhibit | ERK | anti-inflammatory | Inhibitor | p38 MAPK | cytokines | p38 |
| 相关产品 | TBHQ | Acetylcysteine | L-Ascorbic acid | Glucosamine | Lidocaine hydrochloride | Lycopene | Indole-3-carbinol | 1-Octanol | Diallyl disulfide |
| 相关库 | 铜死亡化合物库 | 铁死亡化合物库 | 抗结直肠癌中药单体化合物库 | 稀有天然产物库 | 钙通道分子库 | NO PAINS 化合物库 | 高通量筛选天然产物库 | MAPK 抑制剂库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
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