Heparin sodium salt NEW
| Price | $41 | $76 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Heparin sodium salt | CAS No.: 9041-08-1 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Heparin sodium salt |
| Description | Heparin sodium is a sulfated polysaccharide, which belongs to the family of glycosaminoglycans. It is utilized as an anticoagulant and interacted with diverse proteins for numerous important biological activities.Heparin sodium salt (Sodium heparinate) significantly inhibits exosome-cell interactions. |
| Kinase Assay | In vitro assay of CYP17: The in vitro CYP17 inhibitory activity of Galeterone is evaluated using rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing E. coli as the enzyme source. It involves the use of [21-3H]-17α-hydroxypregnenolone as the substrate, and CYP17 activity is measured by the amount of tritiated acetic acid formed during the cleavage of the C-21 side chain of the substrate. IC50 value is obtained directly from plots relating percentage inhibition versus inhibitor concentration over appropriate ranges. |
| In vitro | Heparin contains a speci?c pentasaccharide sequence that binds and activates the plasma proteinase inhibitor AT, which accounts for most of the increase in inhibitory activity toward Factor Xa induced by heparin. Heparin binds, via the speci?c pentasaccharide sequence, to AT is a two-step process, involving formation of an initial complex with a Kd of ～4×10?5M, followed by conformational changes in both the AT and saccharide moieties. Heparin 12-mer binds to FGF2 monomer covalently is able to induce FGFR activation (stimulate mitogenesis). [1] Heparin induces aggregation of platelets in citrated platelet-rich plasma and enhances platelet aggregation and serotonin secretion induced by other agents, and this action of heparin is blocked by substances that elevate platelet cyclic AMP and by EDTA but not by inhibitors of platelet cyclooxygenase. [2] Heparin controls, through a post-translational mechanism, the levels of specific cassettes of positively charged proteases inside mast cells. [3] Heparin activates the inhibition of thrombin by antithrombin by bringing them into close apposition, but there is also a direct activation of inhibition due to an overall conformational change induced by the binding to the core pentasaccharide present in both heparin and heparans. [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 20 mg/mL, Sonication is recommended. |
| Keywords | Heparin sodium salt |
| Inhibitors Related | Stavudine | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Oxyresveratrol | Paeonol | Naringin | Gefitinib |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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