Product Details
| Product Name:
Hispidol |
CAS No.:
5786-54-9 |
| Purity:
≥95% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Hispidol |
| Description | Hispidol ((Z)-Hispidol) ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM. |
| Animal Research | Hispidol is prepapred in corn oil.Rat: To study the effect of the drugs, hispidol (10 or 30 mg/Kg/day in corn oil) is administered orally once in a day, until 5 days after TNBS administration. The doses of 10 or 30 mg/kg are selected based on previous studies. The concentration of the compound inhibiting 70% and 90% (μM) cell-to-cell adhesion is selected and regarded as the in vivo test dose (mg/kg). Sulfasalazine (300 mg/Kg/day) is administered in corn oil as a positive control. On the 6th day, the rats are sacrificed and the severity of colitis and macroscopic ulceration are evaluated by two independent investigators who are blinded to the experiments. The colon tissues (5-7 cm proximal to rectum) are cut and used to measure the amount of myeloperoxidase and for the histological examinations[1]. |
| In vitro | Hispidol demonstrates potent inhibitory effects on TNF-α-induced adhesion of monocytes to colonic epithelial cells and LPS-induced TNF-α expression, making it a promising candidate for inflammatory bowel disease (IBD) drug development. This compound not only inhibits TNF-α expression effectively (>70%)—a critical event in IBD progression—but also suppresses AP-1 transcriptional activity, which is essential for high levels of TNF-α expression. |
| In vivo | Oral administration of hispidol suppresses TNBS-induced colitis in a dose-dependent manner. Body weight loss and colon tissue edematous inflammation are recovered significantly. The oral administration of hispidol suppresses significantly and dose-dependently TNBS-induced rat colitis. A higher dose (30 mg/kg) of hispidol shows a similar recovery effect to that of 300 mg/kg sulfasalazine. In the colon tissues, TNBS induces a dramatic increase in the level of MPO, a biochemical marker of inflammation, which is suppressed significantly by hispidol in a dose-dependent manner. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 6.25 mg/mL (24.58 mM), Sonication is recommended.
|
| Keywords | inhibit | Hispidol | TNF Receptor | Tumor Necrosis Factor Receptor | TNFR | Inhibitor |
| Inhibitors Related | Cepharanthine | Acetylcysteine | Acefylline | Glucosamine | Thalidomide | Taurochenodeoxycholic Acid | Apremilast | Pomalidomide | Bergenin | Lenalidomide | Fisetin | Linalool |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Angiogenesis related Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Cardiovascular Disease Compound Library | Immuno-Oncology Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
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$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States