![Hypericin](/ProductImageEN/2023-10/Large/f2aec9fe-8d93-4a77-b360-62b4b52365bb.jpg)
Hypericin NEW
Price | $20 | $10 | $1 |
Package | 1kg | 100kg | 1000kg |
Min. Order: | 1kg |
Supply Ability: | 10 tons |
Update Time: | 2024-08-15 |
Product Details
Product Name: Hypericin | CAS No.: 548-04-9 |
EC-No.: 208-941-0 | Min. Order: 1kg |
Purity: 0.99 | Supply Ability: 10 tons |
Release date: 2024/08/15 |
Hypericin is a naphthodianthrone, a red-colored anthraquinone-derivative, which, together with hyperforin, is one of the principal active constituents of Hypericum (Saint John's wort). Hypericin is believed to act as an antibiotic, antiviral and non-specific kinase inhibitor. Hypericin may inhibit the action of the enzyme dopamine β-hydroxylase, leading to increased dopamine levels, although thus possibly decreasing norepinephrine and epinephrine.
It was initially believed that the anti-depressant pharmacological activity of hypericin was due to inhibition of monoamine oxidase enzyme. The crude extract of Hypericum is a weak inhibitor of MAO-A and MAO-B. Isolated hypericin does not display this activity, but does have some affinity for NMDA receptors. This points in the direction that other constituents are responsible for the MAOI effect. The current belief is that the mechanism of antidepressant activity is due to the inhibition of reuptake of certain neurotransmitters.
The large chromophore system in the molecule means that it can cause photosensitivity when ingested beyond threshold amounts. Photosensitivity is often seen in animals that have been allowed to graze on St. John's Wort. Because hypericin accumulates preferentially in cancerous tissues, it is also used as an indicator of cancerous cells. In addition, hypericin is under research as an agent in photodynamic therapy, whereby a biochemical is absorbed by an organism to be later activated with spectrum-specific light from specialized lamps or laser sources, for therapeutic purposes. The antibacterial and antiviral effects of hypericin are also believed to arise from its ability for photo-oxidation of cells and viral particles.
Hypericin derives from polyketides cyclisation.
The biosynthesis of hypericins is in the polyketide pathway where an octaketide chain goes through processes of cylizations and decarboxylations form emodin anthrone which are believed to be the precursors of hypericin. Oxidization reactions yield protoforms which then are converted into hypericin and pseudohypericin. Theses reactions are photosensitive and take place under exposure to light and using the enzyme Hyp-1.
Name | Hypericin | EINECS | 208-941-0 |
CAS No. | 548-04-9 | Density | 1.915 g/cm3 |
PSA | 155.52000 | LogP | 5.39180 |
Solubility | 1 M NaOH: 10 mg/mL | Melting Point | 299-301 °C |
Formula | C30H16O8 | Boiling Point | 1020.3 °C at 760 mmHg |
Molecular Weight | 504.45 | Flash Point | 584.6 °C |
Transport Information | UN 2811 | Appearance | Fine Powder |
Appearance and character:Brown powder
Density: 1.915g /cm3
Boiling point: 1020.3ºC at 760 mmHg
Melting point: 299-301°C
Flash point: 584.6ºC
Refractive index: 2.13
Storage condition: Store at +4ºC
Company Profile Introduction
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$0.00/1kg |
VIP2Y
|
Hebei Kingfiner Technology Development Co.Ltd
|
2024-05-21 | |
$0.00/1kg |
VIP1Y
|
Shaanxi TNJONE Pharmaceutical Co., Ltd
|
2024-03-29 | |
$0.00/25KG |
VIP5Y
|
Hebei Mojin Biotechnology Co., Ltd
|
2023-10-13 | |
$0.00/25kg |
Shaanxi Haibo Biotechnology Co., Ltd
|
2023-09-05 | ||
$0.00/25kg |
VIP2Y
|
Bonerge(Hunan) Lifescience Co., Ltd.
|
2023-05-05 | |
$30.00/1KG |
VIP3Y
|
Hebei Guanlang Biotechnology Co., Ltd.
|
2023-04-03 | |
$0.00/1KG |
VIP3Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2022-10-13 | |
$0.00/10g |
VIP3Y
|
Changsha Staherb Natural Ingredients Co., Ltd.
|
2022-08-10 | |
$15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-11 | ||
$130.00/10ml |
Baoji Guokang Healthchem co.,ltd
|
2021-06-07 |
- Since: 2020-05-25
- Address: Zhanggeji Village, Fengjiazhai Town, Guangzong County, Xingtai City, Hebei Province
17531190177