INT-777 NEW
Price | $139 | $198 | $347 |
Package | 1mg | 2mg | 5mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-13 |
Product Details
Product Name: INT-777 | CAS No.: 1199796-29-6 |
Purity: 99.89% | Supply Ability: 10g |
Release date: 2024/11/13 |
Product Introduction
Bioactivity
名称 | INT-777 |
描述 | INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats. |
体外活性 | INT-777 (3 μM) increases ATP production in the human enteroendocrine cell line NCI-H716 in a cAMP-dependent manner.[2] INT-777 (10 μM) decreased Isc and increased TEER when added to the serosal side of serosal-stripped distal colon segments. The effect of INT-777 on basal secretion was reduced in neuronal-free and TTX-treated muco-submucosal preparations.[3] |
体内活性 | INT-777 (1 μM/min/kg; orally) is a potent choleretic that prevents activation and binding of carboxy-CoA, favoring its biliary-hepatic shunt pathway in HF-fed TGR5-Tg males, and shows absorption and strong choleretic effect in mice.[1] INT-777 (30 mg/kg/day; orally) increases energy expenditure and reduces hepatic steatosis and adiposity in high-fat-fed TGR5-Tg mice.[2] |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | Ethanol : 50 mg/mL (110.95 mM) DMSO : 30 mg/mL (66.57 mM), Sonication is recommended. |
关键字 | INT777 | INT 777 | INT-777 |
相关产品 | Ursodeoxycholic acid sodium | SBI-115 | BAR502 | TC-G 1005 | Deoxycholic acid | Triamterene | L-692429 | Deoxycholic acid sodium salt | BAR501 | Hyodeoxycholic acid | PEN (human) aceate | SB756050 |
相关库 | 经典已知活性库 | 膜蛋白靶向化合物库 | 已知活性化合物库 | GPCR靶点分子库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
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