Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >INT-777
INT-777
  • INT-777

INT-777 NEW

Price $139 $198 $347
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-13

Product Details

Product Name: INT-777 CAS No.: 1199796-29-6
Purity: 99.89% Supply Ability: 10g
Release date: 2024/11/13

Product Introduction

Bioactivity

名称INT-777
描述INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.
体外活性INT-777 (3 μM) increases ATP production in the human enteroendocrine cell line NCI-H716 in a cAMP-dependent manner.[2] INT-777 (10 μM) decreased Isc and increased TEER when added to the serosal side of serosal-stripped distal colon segments. The effect of INT-777 on basal secretion was reduced in neuronal-free and TTX-treated muco-submucosal preparations.[3]
体内活性INT-777 (1 μM/min/kg; orally) is a potent choleretic that prevents activation and binding of carboxy-CoA, favoring its biliary-hepatic shunt pathway in HF-fed TGR5-Tg males, and shows absorption and strong choleretic effect in mice.[1] INT-777 (30 mg/kg/day; orally) increases energy expenditure and reduces hepatic steatosis and adiposity in high-fat-fed TGR5-Tg mice.[2]
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度Ethanol : 50 mg/mL (110.95 mM)
DMSO : 30 mg/mL (66.57 mM), Sonication is recommended.
关键字INT777 | INT 777 | INT-777
相关产品Ursodeoxycholic acid sodium | SBI-115 | BAR502 | TC-G 1005 | Deoxycholic acid | Triamterene | L-692429 | Deoxycholic acid sodium salt | BAR501 | Hyodeoxycholic acid | PEN (human) aceate | SB756050
相关库经典已知活性库 | 膜蛋白靶向化合物库 | 已知活性化合物库 | GPCR靶点分子库

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$3100.00/100mg
VIP3Y
TargetMol Chemicals Inc.
2024-10-28
$0.00/1kg
VIP5Y
Hebei Yanxi Chemical Co., Ltd.
2023-10-09
$139.00/1mg
VIP3Y
TargetMol Chemicals Inc.
2024-11-13
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hills
INQUIRY