Ipriflavone NEW
| Price | $42 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Ipriflavone | CAS No.: 35212-22-7 |
| Purity: 99.87% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Ipriflavone |
| Description | Ipriflavone (Osteofix) (Osteofix) is a feed additive and a catabolic agent. It is used to inhibit bone resorption. |
| Cell Research | Cells are exposed to various concentrations of Ipriflavone for 24, 48, 72 and 96 hours. Cells are treated with trypan blue to estimate the number of viable cells. For thymidine incorporation analysis, [3H]Thymidine (1 μCi) is added, and cells are harvested onto glass fiber filters 4 hours later. Radioactivity is determined by scintillation counting.(Only for Reference) |
| In vitro | Ipriflavone significantly inhibits the growth of MDA-231 xenograft tumors; treated mice exhibited a reduction in tumor volume by 25% and 45% and a decrease in weight by 47% and 63% compared to the control group, respectively, along with extended survival times of the tumor-bearing mice. Additionally, oral administration of 12 mg of Ipriflavone markedly suppressed the development of osteolytic metastases in bone metastatic cancer, impeded the progression of osteolytic lesions, and reduced the number of osteoclasts adjacent to cancer cells. |
| In vivo | Ipriflavone modulates the differentiation and biosynthesis of human bone marrow stromal osteoprogenitor cells (BMCs) by enhancing the expression of certain key matrix proteins and promoting mineralization. In cultured murine undifferentiated osteoblasts, 10 mM Ipriflavone significantly inhibits bone resorption augmented by glycation end products. At a 50 mM dose, Ipriflavone does not induce apoptosis in MDA-231 cells. Additionally, Ipriflavone exhibits a dose-dependent inhibition of MDA-231 cell proliferation and DNA synthesis and impedes ligand-induced phosphorylation of Tyr845 in the EGFR. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 2 mg/mL (7.13 mM) DMSO : 60 mg/mL (214.04 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | Inhibitor | inhibit | Ipriflavone |
| Inhibitors Related | 4'-Methoxyresveratrol | FPS-ZM1 | Azeliragon |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | ReFRAME Related Library | Drug Repurposing Compound Library | Drug-Fragment Library | Inhibitor Library | Orally Active Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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