Isoxadifen-ethyl

Foreign Name: Isoxadifen - ethyl Aliases: Ethyl 4,5 - dihydro - 5,5 - diphenyl - 1,2 - oxazole - 3 - carboxylate, Herbicide Safener, Isoxadifen - ethyl Chemical Formula: C18H17NO3 Molecular Weight: 295.3325 EINECS Registration Number: 443 - 870 - 0 CAS Registration Number: 163520 - 33 - 0 Customs Code: 2934999099 Structural Formula: II. Physicochemical Properties - **Melting Point**: 87 °C (Another source claims 260 °C) - **Boiling Point**: 407.7 °C at 760 mmHg (Another source claims 552 °C) - **Density**: 1.15 g/cm³ - **Appearance**: White powder - **Flash Point**: 166.8 °C - **Vapor Pressure**: 7.43E - 07 mmHg at 25 °C - **Solubility**: Sparingly soluble in water, readily soluble in most organic solvents III. Applications Isoxadifen - ethyl is mainly applied in herbicides for corn fields and paddy fields, including nicosulfuron, rimsulfuron, foramsulfuron, mesotrione, (R)-fenoxaprop - P - ethyl (1:1), etc. It can serve as a safener for these herbicides, reducing the phytotoxicity of herbicides to crops without reducing their efficacy. Companies such as Bayer and DuPont have developed a series of herbicide varieties with isoxadifen - ethyl as a safener. The ratio of isoxadifen - ethyl to nicosulfuron is 1:4, to rimsulfuron is 1:2, to foramsulfuron is 1:1, and to mesotrione is 1:2. IV. Hazards Isoxadifen - ethyl has hazardous properties such as flammability, irritancy, corrosiveness, and toxicity. It can cause irritation to the skin, eyes, and respiratory tract, and may even lead to skin damage and chemical burns. Prolonged exposure to it can affect physical health, causing headaches, insomnia, and neurasthenia. At the same time, it also has an impact on the environment, potentially causing water and soil pollution and endangering the ecological environment. When using isoxadifen - ethyl, appropriate protective measures should be taken, such as wearing suitable protective gloves, masks, safety goggles, and other protective equipment. Ensure good ventilation during operation to avoid inhalation and ingestion. If exposed to this chemical, immediately rinse with a large amount of clean water and consult a doctor for treatment. V. Development History and Patents Isoxadifen - ethyl was initially developed by Aventis (later acquired by Bayer) and launched in 1994. Its patent protection period expired in 2014. Currently, there are few domestic manufacturers of isoxadifen - ethyl, but there are already several synthetic routes available.