Itraconazole

Itraconazole name

Itraconazole in Chinese

itraconazole

Chinese alias 4 - [4 - (4 - (4 - [[cis - 2 - (2, 4 - dichlorobenzene) - 2 - (1 h - 1, 4-trichlorobenzene triazole - 1 - methyl) - 1, 3 - dioxolane - 4 - base] methoxy] phenyl] piperazine - 1 - base] phenyl] - 2 - [(rs) 1-1 - methyl propyl] 1, 4-trichlorobenzene triazole - 3 - ketone | In accordance with his health | linnemann | the thiazole | of Atlantis 4 - [4 - (4 - (4 - [[2 - (2, 4 - dichlorobenzene) - 2 - (1 h - 1, 4-trichlorobenzene triazole - 1 - methyl) - 1, 3 - dioxolane - 4 - base] methoxy] phenyl] - 1 - piperazine base] phenyl] - 2, 4 - dihydro - 2 - (1 - methyl propyl) - 3 h - 1, 4-trichlorobenzene triazole - 3 - ketone

More English nicknames

Biological activity of itraconazole

Description Itraconazole is an antifungal agent.

Related category

Signal path > > Autophagy > > autophagy

Signal path > > Anti-infection > > fungus

Research Field > > infection

Reference literature

[1]. Kim, J., et al., Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell, 2010. 17(4): p. 388-99.

[2]. Chong, C.R., et al., Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol, 2007. 2(4): p. 263-70.

[3]. Shi, W., et al., Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling. J Med Chem, 2011. 54(20): p. 7363-74.

[4]. Olkkola, K.T., J.T. Backman, and P.J. Neuvonen, Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole. Clinical Pharmacology & Therapeutics, 1994. 55(5): p. 481-485.

Physical and chemical properties of itraconazole

Density 1.4± 0.1g /cm3

Boiling point 850.0±75.0 °C at 760 mmHg

Melting point 166°C

Molecular formula C35H38Cl2N8O4

Molecular weight 705.633

Flash point 467.9±37.1 °C

Accurate quality 704.239319

PSA 104.70000

LogP is 4.35

Appearance properties grayish white crystalline solid

Vapor pressure 0.0±3.2 mmHg at 25°C

Refractive index 1.678

Storage conditions 2-8°C

Stable. Incompatible with strong oxidizing agents. Stable. Incompatible with strong oxidizing agents.

Water-soluble chloroform: 50 mg/mL, clear, colorless

Molecular structure

1. Molar refractive index: 189.33

2, molar volume (cm3/mol) : 502.0

3. Isotropic volume (90.2K) : 1372.7

4. Surface tension (dyne/cm) : 55.9

5, polarization (10-24cm3) : 75.05

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1. Properties: Crystallized from toluene

2. Melting point (ºC) : 166.2

3. Solubility: almost insoluble in water and dilute acid solution