K-80003 NEW
| Price | $106 | $169 | $297 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: K-80003 | CAS No.: 1292821-90-9 |
| Purity: 99.76% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | K-80003 |
| Description | K-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth. |
| In vitro | In MCF-7 cells, cotreatment with K-80003 inhibits the TNFα-induced colocalization of tRXRα with p85α in the cytoplasm, leading to tRXRα nuclear localization. Western blotting reveals that the K-80003-stabilized tetrameric form of tRXRα is exclusively present in the nuclear fraction, while the tRXRα monomer is distributed in both nuclear and cytoplasmic fractions [1]. |
| In vivo | K-80003, a potent inhibitor of AKT activation by all-trans-retinoic acid, exhibits enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. K-80003 has high affinity for RXRα but lacks COX inhibitory activity [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (178.36 mM), Sonication is recommended. |
| Keywords | K-80003 | K 80003 | TX 803 | TX803 | K80003 |
| Inhibitors Related | Ethyl gallate | Oridonin | Capivasertib | SKLB-163 | Scutellarin | Methyl-Hesperidin | Artemisinin | Honokiol | (E)-Akt inhibitor-IV | 2,3-Butanediol | MK-2206 dihydrochloride | AKT Kinase Inhibitor |
| Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
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