Product Details
| Product Name:
KA2507 |
CAS No.:
1636894-46-6 |
| Purity:
99.14% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | KA2507 |
| Description | KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM. |
| In vitro | At concentrations selective for HDAC6 inhibition, KA2507 did not inhibit in vitro proliferation of mouse or human cancer cells. |
| In vivo | KA2507 (100-200 mg/kg; p.o.; daily; for 20 days) inhibits tumor growth in the syngeneic B16-F10 mouse melanoma model and shows antitumor efficacy in CT26 and MC38 colorectal cancer models. Tumor sample analysis reveals that at efficacious doses, KA2507 modulates biomarkers of antitumor immunity, resulting in reduced STAT3 activation (measured by phospho-STAT3), decreased PD-L1 expression, and increased MHC class I expression. However, KA2507 exhibits poor oral bioavailability (mice 15%) and Cmax (mice 300 ng/mL) following oral administration (mice 200 mg/kg). [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (186.15 mM), Sonication is recommended.
|
| Keywords | KA2507 | KA 2507 | modulatory | KA-2507 | colorectal | Histone deacetylases | immune | cancer | antitumor | Inhibitor | melanoma | HDAC | inhibit |
| Inhibitors Related | Valproic acid sodium salt | Panobinostat | Theophylline monohydrate | Sodium 4-phenylbutyrate | Vorinostat | Acefylline | Curcumin | Valproic Acid | Parthenolide | 4-Phenylbutyric acid | Theophylline | Methyl L-histidinate dihydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Epigenetics Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Aging Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/25mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-23 |
United States