Karbomer

Carb0mer is a high molecular polymer crosslinked by acrylic acid and allyl sucrose or allyl pentaerythritol. It was first produced by G00drich Company in the United States, and its trade name is Carb0p01. China Pharmacopoeia 2005 edition has been included. This product is a loose white powder with acidity, hygroscopicity and special slight odor. It can be dissolved in water, ethanol and glycerin. The molecule contains 56%~58% carboxyl group, so it is weakly acidic. When carbomer is dispersed in water, due to the repulsion between negative charges generated by carboxyl ionization, the crimped polymer expands and expands in volume. The pH of 0.5% aqueous dispersion is 2.7~3.5. The 1% aqueous dispersion can be neutralized with alkaline substances to form gel. The concentration of common aqueous dispersion is 0.1%~3.0%. Pharmacology This product is a kind of hydrogel, which is composed of solid phase (i.e. carbomer) and liquid phase (water) as dispersion medium. Carbomer is a polyacrylic acid polymer cross-linked with pentaerythritol allyl ether or sucrose. Based on its hydrogel properties, this Chemicalbook can adhere to the surface of the cornea and retain liquid. The structure of the gel will be destroyed by the salt in the tears, releasing the water. The main functions of carbomer application are thickening, suspension, emulsification, etc. It can be used as gel agent, adhesive, coating material, rheological improver (humidifier, lubricant, suspension aid, stabilizer), etc. in pharmaceutics. It is widely used, especially in new drug delivery systems. It has been widely used at home and abroad. Overview Carb0mer is a high molecular polymer crosslinked by acrylic acid and allyl sucrose or allyl pentaerythritol. It was first produced by G00drich Company in the United States, and its trade name is Carb0p01. China Pharmacopoeia 2005 edition has been included. Chemical properties Carbomer is a loose white powder with acid, hygroscopicity and special slight odor. It can be dissolved in water, ethanol and glycerin. The molecule contains 56%~58% carboxyl group, so it is weakly acidic.