Ketoconazole
| Price | $150 | $120 | $100 |
| Package | 1kg | 25kg | 100kg |
| Min. Order: | 1kg |
| Supply Ability: | 20 Tons |
| Update Time: | 2023-09-25 |
Product Details
| Product Name: Ketoconazole | CAS No.: 65277-42-1 |
| Min. Order: 1kg | Purity: 99% |
| Supply Ability: 20 Tons | Release date: 2023/09/25 |
Product Details:
| Product Name | Ketoconazole |
| CAS NO. | 65277-42-1 |
| Purity | 99% |
| Melting point | 146ºC |
| Boiling point | 753.4±60.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Usage | Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.Target: CYP3A4 CYP24A1Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligospermia, and decreased testosterone levels, in men being treated for chronic mycotic infections [1]. Ketoconazole also is a cytochrome P450 inhibitor [2].Ketoconazole (KTZ), on the antischistosomal potential of these quinolines against Schistosoma mansoni infection by evaluating parasitological, histopathological, and biochemical parameters. Mice were classified into 7 groups: uninfected untreated (I), infected untreated (II), infected treated orally with PZQ (1,000 mg/kg) (III), QN (400 mg/kg) (IV), KTZ (10 mg/kg)+QN as group IV (V), HF (400 mg/kg) (VI), and KTZ (as group V)+HF (as group VI) (VII). KTZ plus QN or HF produced more inhibition (P<0.05) in hepatic CYP450 (85.7% and 83.8%) and CYT b5 (75.5% and 73.5%) activities, respectively, than in groups treated with QN or HF alone. This was accompanied with more reduction in female (89.0% and 79.3%), total worms (81.4% and 70.3%), and eggs burden (hepatic; 83.8%, 66.0% and intestinal; 68%, 64.5%), respectively, and encountering the granulomatous reaction to parasite eggs trapped in the liver.[3] CYP24A1 inhibitor enhances antiproliferative effects, increases systemic calcitriol exposure, and promotes the activation of caspase-independent apoptosis pathway.[4] |
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Company Profile
Yisheng Technology (Hefei) Co., Ltd. is a high-tech enterprise engaged in the area of chemical products. Our company’s main products includes pharmaceutical intermediates, plant extracts, chemical reagent, animal pharmaceutical, agrochemical intermediates, antibiotic etc..
We have import and export authority. Our products have been exported to more than 30 countries in the world. Based on the advantage of both trade and manufacture, we have been strictly managing to make the whole trade process provide customers with all-round services such as R&D, quality control, logistics and so on. We firmly believe that quality is the life of our company and that customer’s success is our success.
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Why Choose Us
1. Quality is our culture. We cooperate with research institutions,strictly control the process from raw material to finished product
2. Time is the gold.Fast shipment by reputed shipping line.
3. Customer comes first. We provide reasonable price, high quality product and prompt shipment.
4. Full experience of large numbers containers loading in Chinese sea port.
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China- Since: 2022-02-23
- Address: Room 914, Vanke Center, intersection of Qianshan Road and Silihe Road, Luyang District, Hefei City,