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Postion:Product Catalog >API>Antipyretic analgesics>Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)>Ketoprofen
Ketoprofen
  • Ketoprofen
  • Ketoprofen

Ketoprofen NEW

Price $5 $0.1
Package 1KG 1000KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-04-16

Product Details

Product Name: Ketoprofen CAS No.: 22071-15-4
Min. Order: 1KG Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/04/16
Lead time: In stock, ready for shipment Packaging: bag/bottle/drum/IBC
Delivery: By express, by air, by sea Origin: Manufacturer, advantage product
COA, MSDS: Available, contact us for details Name: Tina

 1. Materials information

Names

Nameketoprofen
SynonymMore Synonyms

 ketoprofen Biological Activity

DescriptionKetoprofen is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively.
Related Catalog
Research Areas >> Inflammation/Immunology
Target

COX-1:2 nM (IC50, in human blood monocytes)

COX-2:26 nM (IC50, in human blood monocytes)

In VitroKetoprofen (Compound 2) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].
In VivoKetoprofen (0.32-10 mg/kg, s.c) dose-dependently inhibits acid-induced depression of nesting (IC50, 2.05 mg/kg), and reverses CFA-induced such depression at 0.1-10 mg/kg, with an IC50 of 0.18 mg/kg in mice[2].
Animal AdminFirst, Ketoprofen (0.1-1.0 mg/kg) and morphine (0.1-1.0 mg/kg) are evaluated for their effectiveness to block U69,593-induced depression of nesting. For these studies, Ketoprofen or morphine is administered 30 min before nesting, 1.0 mg/kg U69,593 is administered 15 min before nesting, and each set of conditions is tested in a group of six mice[2].
References

[1]. Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12(4):533-7.

[2]. Negus SS, et al. Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice. Pain. 2015 Jun;156(6):1153-60.

 Chemical & Physical Properties

Density1.2±0.1 g/cm3
Boiling Point431.3±28.0 °C at 760 mmHg
Melting Point93-96°C
Molecular FormulaC16H14O3
Molecular Weight254.281
Flash Point228.8±20.5 °C
Exact Mass254.094299
PSA54.37000
LogP2.81
Vapour Pressure0.0±1.1 mmHg at 25°C
Index of Refraction1.592

 MSDS

ketoprofen MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • UE7570000

  • CHEMICAL NAME :

  • Propionic acid, 2-(3-benzoylphenyl)-

  • CAS REGISTRY NUMBER :

  • 22071-15-4

  • LAST UPDATED :

  • 199801

  • DATA ITEMS CITED :

  • 23

  • MOLECULAR FORMULA :

  • C16-H14-O3

  • MOLECULAR WEIGHT :

  • 254.30

  • WISWESSER LINE NOTATION :

  • QVY1&R CVR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Human - man

  • DOSE/DURATION :

  • 5714 ug/kg

  • TOXIC EFFECTS :

  • Liver - hepatitis (hepatocellular necrosis), zonal Liver - jaundice (or hyperbilirubinemia) hepatocellular Nutritional and Gross Metabolic - body temperature increase

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Human

  • DOSE/DURATION :

  • 714 ug/kg

  • TOXIC EFFECTS :

  • Gastrointestinal - nausea or vomiting

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Human - woman

  • DOSE/DURATION :

  • 80 mg/kg/10D-I

  • TOXIC EFFECTS :

  • Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Unreported

  • SPECIES OBSERVED :

  • Human - child

  • DOSE/DURATION :

  • 300 mg/kg/15D-I

  • TOXIC EFFECTS :

  • Brain and Coverings - other degenerative changes Behavioral - headache Gastrointestinal - nausea or vomiting

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 62400 ug/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 80 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 100 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 350 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Rectal

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 84 mg/kg

  • TOXIC EFFECTS :

  • Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - peritonitis

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 360 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 300 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 550 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 500 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - guinea pig

  • DOSE/DURATION :

  • 1300 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - guinea pig

  • DOSE/DURATION :

  • 450 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 300 mg/kg/30D-C

  • TOXIC EFFECTS :

  • Endocrine - changes in spleen weight Blood - other changes Related to Chronic Data - changes in testicular weight

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 1080 mg/kg/26W-I

  • TOXIC EFFECTS :

  • Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes Related to Chronic Data - death

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Rectal

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 300 mg/kg/30D-C

  • TOXIC EFFECTS :

  • Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 900 mg/kg/5D-I

  • TOXIC EFFECTS :

  • Related to Chronic Data - death

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Mammal - dog

  • DOSE/DURATION :

  • 1092 mg/kg/13W-I

  • TOXIC EFFECTS :

  • Gastrointestinal - ulceration or bleeding from duodenum Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 1 mg/kg

  • SEX/DURATION :

  • female 21 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

MUTATION DATA

  • TEST SYSTEM :

  • Rodent - mouse

  • DOSE/DURATION :

  • 50 mg/kg

  • REFERENCE :

  • MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 393,123,1997

 Safety Information

SymbolArticle illustration
GHS06
Signal WordDanger
Hazard StatementsH301-H315-H319-H335
Precautionary StatementsP261-P301 + P310-P305 + P351 + P338
Personal Protective EquipmentEyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard CodesT: Toxic;
Risk PhrasesR25;R36/37/38
Safety PhrasesS26-S45-S36/37/39
RIDADR2811
RTECSUE7570000
Packaging GroupIII
Hazard Class6.1(b)
HS Code2916392000

 Synthetic Route

Previous 1/24 Next
Article illustration

neomenthyldiphe...

216019-59-9

Article illustration

(3-ethenylpheny...

63444-57-5

Article illustration

Sulfuric acid

7664-93-9

Article illustration

3-Pentanone

96-22-0

~88%

Detail
Literature: Albemarle Corporation Patent: US6096920 A1, 2000 ;
Article illustration

carbon monoxide

201230-82-2

Article illustration

3-ethynylbenzop...

69355-34-6

~55%

Article illustration

ketoprofen

22071-15-4

Article illustration

3-(3-benzoylphe...

41652-24-8

Literature: Tetrahedron Letters, , vol. 32, # 15 p. 1769 - 1770
Article illustration

(+)-α-(3-...

22161-82-6

~86%

Article illustration

ketoprofen

22071-15-4

Literature: Chen, Fener; Liu, Jidong; Shao, Lanying; Yan, Qiongjiao Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 8 p. 989 - 992

 Precursor & DownStream

Precursor  8

Previous 1/2 Next

  • Article illustration CAS#:216019-59-9
    neomenthyldiphe...

  • Article illustration CAS#:63444-57-5
    (3-ethenylpheny...

  • Article illustration CAS#:7664-93-9
    Sulfuric acid

  • Article illustration CAS#:96-22-0
    3-Pentanone

DownStream  9

Previous 1/3 Next

  • Article illustration CAS#:59960-32-6
    Dihydro Ketopro...

  • Article illustration CAS#:586-42-5
    3-Acetylbenzoic acid

  • Article illustration CAS#:579-18-0
    3-BENZOYLBENZOI...

  • Article illustration CAS#:56105-81-8
    (2R)-2-(3-Benzo...

 Customs

HS Code2918300090
Summary2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles172

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

 Synonyms

2-(3-benzoyl-phenyl)propionic acid
Ketoprophene
Ketopron
UNII:90Y4QC304K
Epatec
Lertus
Ketoprofen
Dexal
Menamin
Meprofen
Fastum
MFCD00055790
racemic-Ketoprofen
Orugesic
Iso-K
Oscorel
2-(m-Benzoylphenyl)propionic acid
Oruvail
Toprec
Racemic Ketoprofen
Toprek
2-(3-Benzoylphenyl)propanoic acid
Kefenid
Ketoflam
Orudis
Benzeneacetic acid, 3-benzoyl-α-methyl-
benzeneacetic acid, 3-benzoyl-a-methyl-
ru4733
EINECS 244-759-8
Enantyum
(±)-Ketoprofen
Topre
2-(3-benzoylphenyl)propionic acid
aneol


2. Packaging of materials

  • For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

  • For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                             Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping & Delivery

  • By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

Article illustration


  • By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

Article illustration


  • By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 13213167925

WhatsApp/Skype/Wechat/LINE: 86 13213167925



Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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Henan Fengda Chemical Co., Ltd

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  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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