Ketorolac tromethamine salt NEW
| Price | $44 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Ketorolac tromethamine salt | CAS No.: 74103-07-4 |
| Purity: 99.85% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Ketorolac tromethamine salt |
| Description | Ketorolac tromethamine salt (Ketorolac tris salt) non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, and antipyretic activities. |
| Cell Research | Human osteoblasts cells are exposed to Ketorolac for 24 hours. Thymidine incorporation is assessed by the TopCount Microplate Scintillation and Luminescence Counters through adding [3H]-thymidine to cultures 4 hours prior to harvesting. Cell cycle distribution is determined by using propidium iodide in flow cytometer, and cell apoptosis or necrosis is detected using the Annexin V-FITC Apoptosis Detection Kit. (Only for Reference) |
| Kinase Assay | Inhibition of Prostaglandin Formation: Recombinant COX-1 and COX-2 from rat (rCOX) and human (hCOX) expressed in a baculovirus system are purified and reconstituted with 2 mM phenol and 1 μM hematin. Then the cyclooxygenase activity is measured using a radiometric assay, and the specific activity of the final enzyme preparations used is between 20,000 and 35,000 units. Ketorolac (2 -15 μL) are diluted in DMSO and preincubated with the appropriate recombinant COX (3 -15 ng) at a final concentration of 0.01 to 1000 μM in a reaction mixture (150 μL) containing 50 mM Tris-HCl buffer (pH 7.9), 2 mM EDTA, 10% glycerol, 2 mM phenol, and 1 μM hematin for 10 minutes. The reaction is initiated by addition of [14C]arachidonic acid (50–60 mCi/mmol in a final concentration of 20 μM) and is terminated 45 seconds later by the addition of 100 μL of 0.2 N HCl and 750 μL of distilled water. The total reaction volume is then applied to a 1 mL C18 Sep-pak column that has previously been washed with 2 mL of methanol followed by 5 mL of deionized water. Oxygenated products are eluted with 3 mL of a mixture of acetonitrile/water/acetic acid (50:50:0.1, v/v/v) and quantified by liquid scintillation spectroscopy. |
| In vitro | In models of acetic acid-induced writhing (ID50=0.24 mg/kg), carrageenan-induced hyperalgesia in the paw (ID50=0.29 mg/kg), and carrageenan-induced rat paw edema (ID50=0.08 mg/kg), (R,S)-Ketorolac has demonstrated efficacy. |
| In vivo | Ketorolac inhibits prostaglandin synthesis in HEL cells (COX-1) (IC50=0.025 μM) and LPS-stimulated Mono Mac 6 cells (COX-2) (IC50=0.039 μM). In human osteoblasts (hOB), Ketorolac dose-dependently suppresses thymidine incorporation and proliferation at the G0/G1 phase, blocking cell cycle progression. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 65 mg/mL (172.69 mM) H2O : 14 mg/mL (37.2 mM) Ethanol : 70 mg/mL (186 mM) |
| Keywords | Cyclooxygenase | RS37619 | RS-37619 | Ketorolac tromethamine | Ketorolac tromethamine salt | Inhibitor | inhibit | Ketorolac tris | RS 37619 | COX | Ketorolac |
| Inhibitors Related | Ibuprofen | Acetaminophen | Diclofenac Potassium | Paradol | Indomethacin sodium hydrate |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Inhibitor Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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