L-Ascorbic acid NEW
| Price | $42 | $42 |
| Package | 1g | 1g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: L-Ascorbic acid | CAS No.: 50-81-7 |
| Purity: 99.89% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| Name | L-Ascorbic acid |
| Description | L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy. |
| In vitro | METHODS: Human osteosarcoma cells MG-63 were treated with L-Ascorbic acid (62.5-1000 µM) for 3-24 h. Cell viability was measured by XTT Assay. RESULTS: Cell viability was consistently >95% when cells were treated with L-Ascorbic acid at concentrations of 0-250 µM. When higher concentrations were used, a dose-dependent decrease in cell viability was observed. [1] METHODS: Melanoma cells WM1366 were treated with L-Ascorbic acid (5-50 µM) for 24 h. The expression levels of target proteins were measured using Western Blot. RESULTS: The lowest concentration of L-Ascorbic acid (5 µM) significantly reduced the normoxic expression of HIF-1α protein in human melanoma cell lines. [2] |
| In vivo | METHODS: L-Ascorbic acid (1-4.5 g/kg) was administered intraperitoneally to irradiated C57BL/6 mice to detect radioprotective activity. RESULTS: Administration of 3 g/kg L-Ascorbic acid immediately after exposure significantly increased the survival rate of mice after 7-8 Gy WBI. However, administration of less than 3 g/kg L-Ascorbic acid was ineffective, and 4 g/kg and above was harmful to mice. [3] METHODS: To investigate the effects on amnesia, L-Ascorbic acid (60-160 mg/kg) was administered intraperitoneally to diazepam, scopolamine, and aging-induced amnesic Swiss mice once daily for 3-8 days. RESULTS: L-Ascorbic acid improved learning and memory in aging mice, as evidenced by decreased transfer latency and increased descending latency. [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 35.7 mg/mL (202.8 mM) DMSO : 60 mg/mL (340.68 mM) Ethanol : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | Reactive Oxygen Species | donor | antioxidant | Calcium Channel | Apoptosis | ROS | oxygen | Ca channels | cancer | Electron | channel | Inhibitor | Ca2+ channels | inhibit | L-Ascorbic acid | collagen | L Ascorbic acid | Endogenous Metabolite | reactive | Cav3.2 | species | deposition | LAscorbic acid |
| Related Compound Libraries | 经典已知活性库 | 中药单体化合物库 | 膜蛋白靶向化合物库 | 药物功能重定位化合物库 | 神经保护化合物库 | 烟草单体化合物库 | 抗感染天然产物库 | 离子通道库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
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