Levamisole

Levamisole name

Chinese name Bao Song Ti

English name levamisole

Chinese alias levamisole | (S) - 6 - phenyl - 2,3,5,6 - four hydrogen - imidazole (2, 1 - B] thiazole | alkali levamisole | sinistral,3,5,6-6 - phenyl - 2-4 hydrogen imidazole and thiazole (2, 1 - B]

More English nicknames

Biological activity of levamisole

Description (S) - (-) -levamisole (Levamisole), an insect repellent with immunomodulatory properties. (S) - (-) -levamisole is a positive allosteric regulator (PAM) of α3β2 (EC50=300μM) and α3β4 (EC50=100μM) isoforms of nAChRs. Oral activity [1][2].

Related category

Research Field > > infection

Signal path > > Transmembrane transport > > Choline receptor

Signal path > > Neural signaling Pathway > > Choline receptor

Research Field > > Inflammation/immunity

In vivo studies (S) - (-) -Levamisole (Levamisole) (50μg/ml and 200μg/ml; p.o.; 30 days) prevented weight gain in mice fed a high-fat diet [2].

Reference literature

[1]. Lewis JA, et al. Levamisole: A Positive Allosteric Modulator for the α3β4 Nicotinic Acetylcholine Receptors Prevents Weight Gain in the CD-1 Mice on a High Fat Diet. Curr Pharm Des. 2017; 23 (12) : 1869-1872.

[2]. Mehta KP, et al. Immunoregulatory treatment for minimal change nephrotic syndrome. Arch Dis Child. 1986; 61 (2) : 153-158.

Physical and chemical properties of levamisole

Density 1.3± 0.1g /cm3

Boiling point 344.4±45.0 °C at 760 mmHg

Melting point 230-233 ºC

Molecular formula C11H12N2S

Molecular weight 204.291

Flash point 162.1±28.7 °C

Accurate mass 204.072113

PSA 40.90000

LogP is 1.85

Appearance properties white to off-white crystalline powder

Vapor pressure 0.0±0.8 mmHg at 25°C

Refractive index 1.713

Storage conditions 0-6°C