Linagliptin NEW
Price | Get Latest Price | ||
Package | 10g/Bag | 100g/Bag | 1000g/Bag |
Min. Order: | 100g/Bag |
Supply Ability: | 20 tons |
Update Time: | 2024-11-15 |
Product Details
Product Name: Linagliptin | CAS No.: 668270-12-0 |
EC-No.: 1308068-626-2 | Min. Order: 100g/Bag |
Purity: 99% up, High Density | Supply Ability: 20 tons |
Release date: 2024/11/15 |
Product Information
Product name | Linagliptin |
CAS No. | 668270-12-0 |
Molecular Formula | C25H28N8O2 |
Molecular Weight | 472.55 |
Quality Standard | 98% up by HPLC |
Appearance | Off-white to light-yellow crystalline powder |
COA of Linagliptin
ITEMS | SPECIFICATION | RESULT |
Appearance | Off-white to light-yellow crystalline powder | Light yellow crystalline powder |
Solubility | Soluble in methanol and sparingly soluble in 2-propanol | Conforms |
Identity | (1) The infrared absorption spectrum of the sample in potassium bromide dispersion is concordant with that of a similar preparation of working standard. | Conforms |
(2) The retention time of the main peak of testing solution should be confirmed with the reference solution in HPLC chromatogram. | Conforms | |
Melting point | 200.0 。C - 206.0。C | 203.0。C - 204.5。C |
Loss on drying | ≤ 1.0% | 0.38% |
Residual solvents | Methanol ≤ 3000 ppm Isopropanol ≤ 5000 ppm DMF ≤ 880 ppm Dichloromethane ≤ 600 ppm | ND 4621 ppm ND ND |
Residual on ignition | ≤ 0.1% | 0.08% |
Related substance | Max single impurity ≤ 0.1% Total impurities ≤ 1.0% | 0.07% 0.21% |
Heavy metals | ≤ 10 ppm | Conforms |
Isomer | ≤ 0.15% | ND |
Assay | 98.0% - 102.0% | 99.89% |
Conclusion | The sample complies with the above specification |
Usage
Linagliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4), which degrades incretin-like polypeptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Linagliptin increases the concentration of active incretin hormones, stimulates insulin release in a glucose-dependent manner, and reduces circulating glucagon levels.
Linagliptin in combination with metformin and sulfonylureas, with diet and exercise, can be used for glycemic control in adults with type II diabetes.
Company Information
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- Since: 1996-07-16
- Address: Fujian China ,16F, Huicheng Comm. Complex, 839 Xiahe RD.