Linezolid NEW
| Price | $43 | $77 | $97 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Linezolid | CAS No.: 165800-03-3 |
| Purity: 99.99% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Linezolid |
| Description | Linezolid (PNU-100766), the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and streptococcus. The drug takes effect as the inhibitor of the initiation of bacterial protein synthesis. |
| In vivo | Linezolid effectively inhibits Escherichia coli lacking cellular transcription-translation mechanisms, with an IC50 value of 1.8 mM. Its mode of action primarily involves suppressing the synthesis of early-stage proteins, representing a novel antimicrobial agent that enhances anti-pathogenic activity. Linezolid inhibits the formation of the initiation complex by the E. coli 70S or 30S ribosomal subunit. Due to variations in testing methods and laboratory conditions, discrepancies in Linezolid's MIC (Minimum Inhibitory Concentration) have been noted, yet it consistently displays a narrow sensitivity range, with MIC values for streptococci, staphylococci, and enterococci between 0.5 mg/L and 4 mg/L. Linezolid induces mutations at the 23S rRNA gene binding site. When added to 7H10 agar medium [oleic acid, albumin, dextrose, and catalase], and diluted to final concentrations ranging from 0.125 μg/mL to 4 μg/mL at 50°C-56°C, Linezolid exhibits excellent in vitro activity (MIC values ≤1 μg/mL) against tested strains, including those resistant to SIRE. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 8.4 mg/mL (25 mM) DMSO : 55 mg/mL (163.04 mM) |
| Keywords | inhibit | Inhibitor | Antibiotic | Linezolid | PNU100766 | Bacterial | PNU 100766 |
| Inhibitors Related | Neomycin sulfate | Kanamycin sulfate | Sulfamethoxazole sodium | Doxycycline | Paeonol | Dimethyl sulfoxide |
| Related Compound Libraries | Bioactive Compound Library | Approved Drug Library | Antibiotics Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Bacterial Compound Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Anti-COVID-19 Compound Library | Hematopoietic Toxicity Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
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