LM11A-31 dihydrochloride NEW
Price | $38 | $82 | $121 |
Package | 10mg | 25mg | 50mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-14 |
Product Details
Product Name: LM11A-31 dihydrochloride | CAS No.: 1243259-19-9 |
Purity: ≥98% | Supply Ability: 10g |
Release date: 2024/11/14 |
Product Introduction
Bioactivity
名称 | LM11A-31 dihydrochloride |
描述 | LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagonist. |
体内活性 | LM11A-31 (orally; 50 or 75 mg/kg) administered for 3 months starting at 6-8 months of age prevents and/or reverses atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites in mid-stage male APPL/S mice[2].?LM11A-31 (oral gavage;?50 mg kg/day for 4 weeks) significantly mitigates proNGF accumulation and preserves BRB integrity[1]. |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | H2O : 125 mg/mL (395.23 mM), Sonication is recommended. |
关键字 | cholinergic | proNGF | Inhibitor | inhibit | LM11A-31 | growth | dystrophy | disease | p75 | Neurotensin Receptor | LM-11A-31 dihydrochloride | nerve | neurite | receptor | barrier | neurotrophin | factor | Ligand | LM11A 31 dihydrochloride | blood-brain | LM11A31 dihydrochloride | Alzheimer's | p75NTR | LM11A-31 Dihydrochloride |
相关库 | 经典已知活性库 | 药物功能重定位化合物库 | 血脑屏障通透化合物库 | 抑制剂库 | NO PAINS 化合物库 | 口服活性化合物库 | 临床期小分子药物库 | 已知活性化合物库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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