Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD NEW
| Price | $30 | $44 | $76 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD | CAS No.: 1037589-69-7 |
| Purity: 99.83% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD |
| Description | Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (PF-05231023) is a long-acting fibroblast growth factor 21 (FGF21) analog and FGF21-receptor agonist, suitable for development as a potential treatment for T2DM. |
| In vitro | PF-05231023 is a analog of long-acting fibroblast growth factor 21 [2]. |
| In vivo | Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDsuppresses oxidative-stress-induced inflammation in photoreceptors. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDdecreases the variability of retinal NRF2 levels and displays a trend (non-significant) towards increased NRF2 levels in Akita mice. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDdecreases retinal IL-1β mRNA expression in Akita mice. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDenhances cone-specific arrestin4 expression in Akita mice. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDrestores photoreceptor morphology in Akita mice. Administration of native FGF21 and Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD(3mg/kg or 10mg/kg; subcutaneously twice a week for two weeks) improves glucose tolerance and liver insulin sensitivity in Zucker rats. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD(10 mg/kg; intraperitoneally injected) reduces retinal inflammation in diabetic mice [3][4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 125 mg/mL (236.50 mM), Sonication is recommended. |
| Keywords | Mal-amido-PEG-2-C2-amido-Ph-C2-CO-AZD | PROTAC Linkers | MalamidoPEG2C2amidoPhC2COAZD | Inhibitor | Mal amido PEG2 C2 amido Ph C2 CO AZD | Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD | inhibit | PF05231023 | PF 05231023 |
| Inhibitors Related | 6-Maleimidocapronic acid | Ferulic Acid | Pazopanib |
| Related Compound Libraries | Bioactive Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
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