Mavacamten
Price | $23 |
Package | 1kg |
Min. Order: | 1kg |
Supply Ability: | 500tons |
Update Time: | 2024-01-08 |
Product Details
Product Name: Mavacamten | CAS No.: 1642288-47-8 |
Min. Order: 1kg | Purity: 99.96% |
Supply Ability: 500tons | Release date: 2024/01/08 |
Chemical Name : Mavacamten(MYK-461)
CAS Number : 1642288-47-8
biological activity
Maveacamten (MYK-461, SAR 439152) is a small molecule regulator of cardiac myosin, which regulates the excessive contraction of sarcomere in hypertrophic cardiomyopathy.
In vitro study
MYK-461 reduces the activity of steady-state ATPase by inhibiting the phosphate release rate of β -cardiac myosin -S1. MYK-461 regulates several steps in the chemical-mechanical cycle of myosin: in addition to reducing the rate-limiting step (phosphate release) in this cycle, MYK-461 also reduces the number of myosin-S1 heads (myosin-S1 heads can interact with actin filaments when the weak binding state changes to the strong binding state). MYK-461 can also reduce the binding rate of myosin to ADP- actin and the release rate of ADP from myosin-S1.
In vivo study
In the mouse model transplanted with myosin heavy chain containing human heterozygous mutation, early and long-term administration of MYK-461 (MYK-461) can inhibit the development of ventricular hypertrophy, myocardial cell disorder and myocardial fibrosis, and reduce the expression of genes related to hypertrophy and fibrosis.
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- Since: 2014-04-18
- Address: Hong Kong
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