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Postion:Product Catalog >MBM-55
MBM-55
  • MBM-55

MBM-55 NEW

Price $187 $313 $455
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: MBM-55 CAS No.: 2083622-09-5
Purity: 99.98% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameMBM-55
DescriptionMBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.
In vitroMBM-55 (0.5-1 μM; 24 hours) induces G2/M phase arrest and accumulation of cells with >4N content in HCT-116 cells. MBM-55 (0.5-1 μM; 24 hours) causes cell apoptosis in a concentration-dependent manner in HCT-116 cells.MBM-55 inhibits MGC-803, HCT-116, Bel-7402 cells proliferation with IC50s of 0.53, 0.84, 7.13 μM, respectively[1].
In vivoIn female BALB/c nu/nu mice bearing HCT-116 xenografts, MBM-55 (20 mg/kg; i.p.) exhibits good antitumor activity and a well-tolerated dose schedule. MBM-55 (1.0 mg/kg; i.v.) shows the CL, Vss, T1/2, AUC0-t, and AUC0-∞ values of 33.3 mL/min/kg, 2.53 L/kg, 1.72 hours, 495 ng/h/mL and 507 ng/h/mL, respectively[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 120 mg/mL (240.70 mM), Sonication is recommended.
KeywordsMBM-55 | Inhibitor | arrest | proliferation | antitumor | Apoptosis | cycle | cell | selectivity | inhibit | MBM 55 | Nek2 | MBM55
Inhibitors RelatedRibociclib | Cromolyn sodium | CHIR-99021 | sodium lauroyl-α-hydroxyethyl sulfonate | 4-Chloro-2'-bromoacetophenone | Artemisinin | CASIN | Imatinib | 2,3-Butanediol | Sodium Oxamate | Abemaciclib | Sodium salicylate
Related Compound LibrariesBioactive Compound Library | Pain-Related Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Inhibitor Library | Neuroprotective Compound Library | Anti-Prostate Cancer Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Recommended supplier

Product name Price   Suppliers Update time
$1670.00/25mg
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TargetMol Chemicals Inc.
2024-10-28
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$0.00/1Box
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Shanghai Affida new material science and technology center
2024-04-11
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TargetMol Chemicals Inc.
2024-11-19
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hills
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