Mertansine NEW
| Price | $30 | $64 | $98 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-08 |
Product Details
| Product Name: Mertansine | CAS No.: 139504-50-0 |
| Purity: 99.76% | Supply Ability: 10g |
| Release date: 2024/11/08 |
Product Introduction
Bioactivity
| 名称 | Mertansine |
| 描述 | Mertansine is a tubulin inhibitor and an antibody-conjugable maytansinoid alkaloid. The IC50 of Mertansine against HCT-15 and A431 cells is 0.750 and 0.04nM. |
| 体外活性 | METHODS: HCT-15 and A431 cells were incubated with Mertansine (0-3 nM) for 72 hours, then the medium was removed from the plate and replaced with fresh medium. Allow the culture to grow and form colonies for 7-10 days after plating. Cultures were fixed, stained with 0.2% crystal violet in 10% formalin/PBS, and colonies were counted. RESULTS Mertansine can inhibit the growth of HCT-15 and A431 cells. [1] METHODS: 4T1 cells were incubated with Mertansine (5-100 μg/mL) for 4 hours, and cell viability was detected by CCk8. RESULTS Mertansine can inhibit the growth of 4T1 cells.[2] METHODS: MDA-MB-231 cells were incubated with Mertansine (0.001355–13.55μM) for 48 hours, and cancer cell viability was detected by MTT. RESULTS Mertansine can effectively inhibit the proliferation of MDA-MB-231 cells, with an IC50 value of 0.12 μM. [3] |
| 体内活性 | METHODS: The anti-tumor activity of Mertansine (0.5 mg/kg) was evaluated in mice with orthotopic 4T1 tumors. RESULTS Cancer cell apoptosis was significantly increased, and the effect was dose-dependent. [2] METHODS: The in vivo therapeutic properties of Mertansine were evaluated using MDA-MB-231 triple-negative breast tumor mice. Mertansine was administered every 3 days for a total of four injections at a dose of 0.8 mg/kg. RESULTS Mertansine demonstrated modest inhibition of cancer cell growth in MDA-MB-231 triple-negative mammary tumor mice.[3] |
| 存储条件 | store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice. |
| 溶解度 | DMSO : 83.33 mg/mL (112.87 mM), The compound is unstable in solution, please use soon. H2O : < 0.1 mg/mL (insoluble) |
| 关键字 | Maytansinoid DM-1 | Maytansinoid DM 1 | melanoma | Inhibitor | B16F10 | ADC Payload | ADC Cytotoxin | DM-1 | DM 1 | tubulin | Microtubule/Tubulin | antiproliferative | inhibit | mitosis | Mertansine | antitumor | ADC |
| 相关产品 | Dexamethasone acetate | Methylene Blue trihydrate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
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