Metastin (45-54)

Product Name:    KISSPEPTIN-10

CAS:    374675-21-5

MF:    C63H83N17O14

MW:    1302.44

specification:  5mg/vial

Uses: Metastin (45-54) amide has been used in progesterone release experiments from MA-10 cells. It has also been used to induce gonadal differentiation in clownfish.

Uses: Metastin (45-54) is a potent and selective agonist of AXOR12 and hOT7T175.

Kisspeptin 10/Metastin Description

Metastin (45-54) is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product. It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)). Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM). It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin.

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