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Postion:Product Catalog >API>Respiratory Drugs>Asthma drugs>Montelukast sodium
Montelukast sodium
  • Montelukast sodium
  • Montelukast sodium

Montelukast sodium NEW

Price Get Latest Price
Package 1kg
Min. Order: 1kg
Supply Ability: 20tons
Update Time: 2024-04-18

Product Details

Product Name: Montelukast sodium CAS No.: 151767-02-1
EC-No.: 604-813-7 Min. Order: 1kg
Purity: 99% Supply Ability: 20tons
Release date: 2024/04/18
ItemsStandardResults
APPEARANCEOff white to white powderWhite powder
IDENTIFICATIONA: IR
B: Retention time
Complies
Complies
WATER0.5%0.06%
HEAVY METALS≤0.002%Complies
ISOMERSSFBD1≤0.15%Undetected

SFBD2≤0.15%Undetected

SFBE≤0.15%Undetected
RELATED SUBSTANCESSFBA-1≤0.15%0.04%

SFBMA≤0.15%Undetected

CHLORO-SFB≤0.15%0.05%

DiSFBMA-SFB≤0.15%0.02%

Methyl-SFB≤0.15%Undetected

Pentafluoro-phenol≤0.15%Undetected

Amino-SFB≤0.15%Undetected

Any unknown impurity≤0.1%0.04%

Total impurity≤1.0%0.21%
RESIDUE SOLBENTSMethanol≤3000ppmUndetected

Isopropyl alcohol≤5000ppm19ppm

Dichloromethane≤600ppmUndetected

Tetrahydrofuran≤720ppmUndetected

Acetic acid≤5000ppmUndetected

Toluene≤890ppmUndetected

Chlorobenzene≤360ppmUndetected

Methyl tert-butyl ether≤5000ppm103ppm
ASSAY≥99.0%99.8%

Product Name: Montelukast sodium
Synonyms: singulair;MONTELUKAST NA;MONTELUKAST SODIUM;mk-476;2-[1-[[1-[3-[2-[(7-chloro-2-quinolyl)]vinyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]-propyl]sulfanylmethyl]cyclopropyl]acetic acid sodium salt;1-[1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic;MK-476, Singulair;Montelukast, Sodium Salt
CAS: 151767-02-1
MF: C35H35ClNNaO3S
MW: 608.17
EINECS: 604-813-7
Melting point: 115 °C(dec.)
Storage temp.: -20°C Freezer, Under Inert Atmosphere

Description:

Montelukast was launched as Singulair in Mexico and Finland for the management of mild to moderate asthma inadequately controlled by inhaled corticosteroids and short-acting beta2-agonists. Montelukast can be obtained by an seven-step synthesis from 3-[2(E)-(7-chloroquinolin-2-yl)vinyl] benzaldehyde. Montelukast is a potent, selective and orally active antagonist of the CysLT1 (formerly called LTD4) receptor, thus blocking the effects of the cysteinyl leukotrienes LTC4, LTD4 and LTE4 on microvascular permeability and the activation of eosinophils.

Montelukast represents the third molecule of this class which has been approved in asthma after pranlukast (1995) and zafirlukast (1996). Montelukast has been studied extensively in placebo-controlled clinical trials, in mildly or severe asthmatic patients challenged with LTD4 or exercise. A variety of acute bronchoconstricting challenges were inhibited or attenuated with all doses used.

Montelukast demonstrated clinically significant improvements in the parameters of asthma control associated with an appreciable improvement in quality of life., reducing days with asthma exacerbations and allowing significant tapering of corticosteroids. Montelukast is well-tolerated and only needs to be administered once a day.

Article illustration

Company Profile Introduction

Shaanxi TNJONE Pharmaceutical Co., Ltd supplies more than 2,000 kinds of products, covering the whole field of health industry, including human APIs, veterinary APIs, food additives, natural nutrition ingredients, feed additives, cosmetic additives, intermediates etc. With global sourcing advantages, the group is fully capable of meeting the one-stop sourcing needs of global customers. Today, Shaanxi TNJONE Pharmaceutical Co., Ltd.'s marketing network has spread over more than 100 countries and regions on five continents, providing professional service for global customers.

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Shaanxi TNJONE Pharmaceutical Co., Ltd

1YR ChinaChina
  • Since: 2019-05-23
  • Address: No. 4C-11-A392, Financial Port, Northwest corner of Fengjing Avenue and Fengxin Road, Fengdong New C
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