Nicotinamide riboside chloride

Nicotinamide ribose chloride (NR-CL) name

Chinese name niacinamide riboside

Pyridinium, 3- (aminocarbonyl) -1-β-d-ribofuranosyl -, chloride (1:1)

Bioactivity of niacinamide ribose chloride (NR-CL)

Nicotinamide riboside chloride is the crystalline form of Nicotinamide riboside chloride, nicotinamide riboside is the precursor vitamin of nicotinamide adenine dinucleotide (NAD[+]). Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, ultimately enhancing oxidative metabolism and preventing metabolic abnormalities induced by high fat diet. Nicotinamide riboside chloride is used in dietary supplements.

Related category

Signal path > > Epigenetics > > Antiaging enzyme

Signal path > > Cell cycle /DNA damage > > Antiaging enzyme

Research Field > > Metabolic disease

target

SIRT1

SIRT3

In vitro study of niacinamide riboside chloride (0.5nm; 24 h) decreased the acetylation status of ndufa9 and sod2 [1]. Western blot analysis [1] cell line: HEK293T cell concentration: 0.5nM Incubation time: 24 h Results: decreased the acetylation state of NDUFA9 and SOD2.

In vivo study of chronic niacinamide riboside chloride (p.o.; 400 mg/kg/ day; For 16 weeks) increased plasma and intracellular NAD[+] levels in a tissue-specific manner [1]. Animal model: 10-week-old C57BL/6J mice [1] Dose: 400 mg/kg administration: P.O. Every day; Results at 16 weeks: Plasma and intracellular NAD[+] levels increased in a tissue-specific manner.

Reference literature

[1] Canto C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6; 15 (6) : 838-47.

Physicochemical properties of niacinamide ribose chloride (NR-CL)

Molecular formula C11H15ClN2O5

Molecular weight 290.70000

Accurate mass 290.06700

PSA 116.89000