Nifuroxazide NEW
| Price | $38 | $54 |
| Package | 100mg | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Nifuroxazide | CAS No.: 965-52-6 |
| Purity: 99.87% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Nifuroxazide |
| Description | Nifuroxazide (Diarlidan) is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STAT1/3/5 transcription. |
| In vivo | Nifuroxazide does not affect the phosphorylation of Akt or MAPK. It inhibits the survival of myeloma cells by reducing the autophosphorylation of Jak kinases, thereby blocking the constitutive phosphorylation of STAT3, but has no effect on normal peripheral blood mononuclear cells. Nifuroxazide decreases the tyrosine phosphorylation of TYK2 and Jak, demonstrating selectivity towards TYK2 and Jak2 without impacting the tyrosine kinases of the EGF receptor or Src kinase. This effect is achieved through the reduction of Jak kinases' autophosphorylation, leading to the inhibition of constitutive phosphorylation of STAT3 in MM (multiple myeloma) cells and the downregulation of the STAT3 target gene, Mcl-1. Consequently, Nifuroxazide reduces the viability of primary myeloma cells and cell lines with activated STAT3 but does not affect normal peripheral blood mononuclear cells. It also blocks the survival signals provided by bone marrow stromal cells to myeloma cells. Compared to interactions with other cellular pathways, Nifuroxazide shows increased cytotoxicity when combined with the histone deacetylase inhibitor Trichostatin or the MEK inhibitor UO126, targeting STAT3. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 18.33 mg/mL (66.61 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | STAT | Antibiotic | Inhibitor | Bacterial | inhibit | Nifuroxazide |
| Inhibitors Related | Neomycin sulfate | Ampicillin sodium | Kanamycin sulfate | Sulfamethoxazole sodium | Doxycycline | Dimethyl sulfoxide |
| Related Compound Libraries | Bioactive Compound Library | Cancer Cell Differentiation Compound Library | Drug Repurposing Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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