NNMTi

Price	$10
Package	1kg

Product Details

Product Name: NNMTi	CAS No.: 42464-96-0
Min. Order: 1kg	Purity: 99%
Supply Ability: Ex 20 tons	Release date: 2022/10/14

WHATSAPP:+8615383008051 WICKR ME: CHRISTINE85

email:109@hebeianda.cn

Use of NNMTi

NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2 μM) and selectively binds to the NNMT substrate-binding site residues[1]. NNMTi promotes myoblast differentiation in vitro and enhances fusion and regenerative capacity of muscle stem cells (muSCs) in aged mice[2].

Name	NNMTi

Description	NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2 μM) and selectively binds to the NNMT substrate-binding site residues[1]. NNMTi promotes myoblast differentiation in vitro and enhances fusion and regenerative capacity of muscle stem cells (muSCs) in aged mice[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	NNMTi (10-30 µM; 96 hours) produces a concentration-related increase in myoblast differentiation on C2C12 myoblast differentiation. 30 µM NNMTi results in 18% MHC-positive myotube nuclei, representing a 45% increase in the extent of myoblast differentiation compared to untreated differentiating myoblasts (12% MHC-positive myotube nuclei)[2].
In Vivo	NNMTi (subcutaneous (SC) injection; 5 mg/kg and 10 mg/kg; 2 weeks (1 week pre-injury and 1 week post-injury)) has an effect on muscle regeneration after injury, it results in 60% and 75% higher incidence of proliferating/active muSCs at 5 mg/kg and 10 mg/kg, respectively. The relative numbers of fibers with an EdU+ myonucleus increased 40% and 48% with NNMTi treatment at 5 mg/kg and 10 mg/kg, respectively. The odds ratio of fused myonuclei for control are 0.58 and 0.53 times the odds at the low and high NNMTi dose, respectively[1]. NNMTi (subcutaneous injection; 10 mg/kg; 1 week) produces no systemic toxicity in mice, the levels of the glucose, cholesterol, plasma proteins, and electrolytes between control and NNMTi-treated samples show no difference in mice. 1-week post-injury daily repeat-dosing of NNMTi is well tolerated with no untoward systemic toxicity or behavioral implications in aged mice[1].
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Room temperature
SMILES	C[N+]1=C2C=CC=C(N)C2=CC=C1.[I-]
References	[1]. Harshini Neelakantan, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019 May;163:481-492. [2]. Harshini Neelakantan, et al. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem

Molecular Formula	C10H11IN2
Molecular Weight	286.11

Company Profile Introduction

Recommended supplier

Product name	Price		Suppliers	Update time
NNMTi	$66.00/1g	VIP2Y	Zibo Hangyu Biotechnology Development Co., Ltd	2024-07-10
NNMTi	$40.00/1box	VIP1Y	Strong peptide cross-border e-commerce Co. LTD	2024-05-30
5-amino-1mq	$50.00/1Box	VIP1Y	Qingdao Xinli Technology Development Co., Ltd.	2024-05-29
5-Amino-1mq	$200.00/1kg	VIP1Y	Hebei Zhuanglai Chemical Trading Co.,Ltd	2024-05-10
NNMTi;5-amino-1MQ/5-amino-1mq	$0.00/1BOX	VIP1Y	Shanghai Affida new material science and technology center	2024-05-09
NNMTi	$10.00/1kg	VIP1Y	Ouhuang Engineering Materials (Hubei) Co., Ltd	2024-04-28
5-amino-1mq	$0.00/1G	VIP1Y	CONTIDE BIOTECH CO.,LTD	2024-04-23
5-amino-1mq	$10.00/10vial		Zhejiang Hangyu API Co., Ltd	2024-04-08
5-amino-1mq	$90.00/1box	VIP1Y	Hebei Kangcang new material Technology Co., LTD	2024-03-22
NNMTi	$0.00/1kg	VIP1Y	Shandong Hanjiang Chemical Co., Ltd	2024-01-11

Product Details

Use of NNMTi

Names

NNMTi Biological Activity

Chemical & Physical Properties

Company Profile Introduction

You may like

Recommended supplier

Hebei Anda Technology Co., LTD

Min. Order:	1kg
Supply Ability:	Ex 20 tons
Update Time:	2022-10-14