Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >Nrf2-IN-1
Nrf2-IN-1
  • Nrf2-IN-1

Nrf2-IN-1 NEW

Price $116 $289 $396
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Nrf2-IN-1 CAS No.: 1610022-76-8
Purity: 99.68% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameNrf2-IN-1
DescriptionNrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).
In vitroNrf2-IN-1 (Compound 4f), that inhibited Nrf2 activity.?4f had a profound growth-inhibitory effect on three AML cell lines, THP-1, HL-60 and U937, and a similar anti-growth effect in a chick embryo model.?Moreover, flow cytometry of AML cells revealed increased apoptosis with 4f (10 μM) treatment for 48 h. The protein levels of cleaved caspase-3 and cleaved poly (ADP-ribose) polymerase were enhanced in all three AML cell types.?Furthermore, Nrf2 protein level was downregulated by 4f.?Upregulation of Nrf2 by tert-butylhydroquinone (tBHQ) or Nrf2 overexpression could ameliorate 4f-induced growth inhibition and apoptosis.?Treatment with 4f reduced both B-cell lymphoma-2 (Bcl-2) expression and Bcl-2/Bcl-2-associated X protein (Bax) ratio, which indicated that 4f induced apoptosis, at least in part, via mitochondrial-dependent signaling.?Therefore, as an Nrf2 inhibitor, the pyrazolyl hydroxamic acid derivative 4f may be a promising agent in AML therapy[1].
In vivoNrf2-IN-1 inhibits tumor growth in chicken eggs?via apoptosis?[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 260 mg/mL (677.31 mM), Sonication is recommended.
KeywordsNrf2-IN-1 | Nrf-2-IN-1 | Nrf2IN1 | Nrf2 IN 1 | Nrf2 | myeloid | leukemia | Keap1-Nrf2 | Inhibitor | inhibit | AML | Acute
Inhibitors RelatedTBHQ | L-Cystine dihydrochloride | Mangiferin | Methyl 3,4-dihydroxybenzoate | Pyridoxine | Resveratrol | Luteolin | CDDO-Im | Curcumin | Ezetimibe | Oltipraz | Pyridoxine hydrochloride
Related Compound LibrariesApoptosis Compound Library | Bioactive Compound Library | Anti-Obesity Compound Library | Hematonosis Compound Library | Antioxidant Compound Library | Inhibitor Library | NO PAINS Compound Library | PPI Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Oxidation-Reduction Compound Library | Transcription Factor-Targeted Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$1520.00/25mg
VIP1Y
TargetMol Chemicals Inc.
2024-11-19
$58.00/2mg
VIP3Y
TargetMol Chemicals Inc.
2024-10-23
$0.00/10mg
VIP1Y
Hubei Chuchang Biotech Co., Ltd.
2024-10-29
$116.00/1mg
VIP3Y
TargetMol Chemicals Inc.
2024-11-19
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hills
INQUIRY