NSC 600157
| Price | Get Latest Price | ||
| Package | 1g | 5g | 10g |
| Min. Order: | 1g |
| Supply Ability: | 1000 |
| Update Time: | 2025-02-21 |
Product Details
| Product Name: NSC 600157 | CAS No.: 31083-55-3 |
| Min. Order: 1g | Purity: 98 |
| Supply Ability: 1000 | Release date: 2025/02/21 |
Product Name: NSC 600157
Synonyms: PRT 4165; PRT-4165; NSC600157; NSC-600157; NSC 600157; 2-(pyridin-3-ylmethylidene)indene-1,3-dione;2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione;2-(3-Pyridylmethylene)-1,3-indandione;NSC 600157;PRT4165;PRT 4165(NSC 600157);1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)-
CAS: 31083-55-3
MF: C15H9NO2
MW: 235.24
PRT-4165 (31083-55-3) is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50?= 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α.1?PRT-4165 inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination?in vitro?and?in vivo?and as such represents a new tool for studying chromatin remodeling.2
Company Profile Introduction
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $2500.00/100mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 | |
| $63.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-10-28 | |
| $713.00/25mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-28 | |
| $38.00/5mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
| $1.00/1KG |
VIP6Y
|
Career Henan Chemical Co
|
2019-12-23 |
China
- Since: 2024-03-12
- Address: Room 02-31, 13 / F, Building 9, Guannan Fuxing Medical Park Phase II, No.58, Guanggu Avenue, East La