NSC 600157
Price | Get Latest Price | ||
Package | 1g | 5g | 10g |
Min. Order: | 1g |
Supply Ability: | 1000 |
Update Time: | 2025-01-11 |
Product Details
Product Name: NSC 600157 | CAS No.: 31083-55-3 |
Min. Order: 1g | Purity: 98 |
Supply Ability: 1000 | Release date: 2025/01/11 |
Product Name: NSC 600157
Synonyms: PRT 4165; PRT-4165; NSC600157; NSC-600157; NSC 600157; 2-(pyridin-3-ylmethylidene)indene-1,3-dione;2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione;2-(3-Pyridylmethylene)-1,3-indandione;NSC 600157;PRT4165;PRT 4165(NSC 600157);1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)-
CAS: 31083-55-3
MF: C15H9NO2
MW: 235.24
PRT-4165 (31083-55-3) is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50?= 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α.1?PRT-4165 inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination?in vitro?and?in vivo?and as such represents a new tool for studying chromatin remodeling.2
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