Product Details
| Product Name:
OX01914 |
CAS No.:
49676-35-9 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | OX01914 |
| Description | OX01914 is a water-soluble and permeable modulator of utrophin that upregulates utrophin protein levels with an EC50 of 20.5 μM. OX01914 can be used in Duchenne muscular dystrophy (DMD) studies [1]. |
| In vitro | OX01914 demonstrates an upregulation of utrophin mRNA in LUmdx and H2K mdx myoblasts at concentrations of 0.1, 10, 40, and 50 μM for 24 hours, and specifically at 30 μM for H2K mdx myoblasts over the same period [1]. Additionally, at concentrations of 1, 3, and 30 μM over 24 hours, OX01914 increases utrophin protein levels approximately threefold in human Duchenne Muscular Dystrophy (DMD) muscle cells [1]. This is corroborated by Western Blot Analysis, which confirms the upregulation of utrophin mRNA in both LUmdx and H2K mdx myoblasts at specified concentrations and duration, and a significant increase in utrophin protein levels in human DMD cells, showcasing OX01914's potential therapeutic effects on muscular dystrophy at the molecular level [1]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States