Pam3CSK4 TFA (112208-00-1 free base) NEW
| Price | $128 | $302 | $453 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Pam3CSK4 TFA (112208-00-1 free base) | CAS No.: 112208-01-2 |
| Purity: 99.01% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| Name | Pam3CSK4 TFA (112208-00-1 free base) |
| Description | Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is a Toll-like receptor 1/2 agonist with EC50 of 0.47 ng/mL for human TLR1/2. |
| In vitro | Pretreatment with high doses of Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) (>25 μg/ml) improves the antimicrobial activity of neutrophils generated directly from mouse bone marrow. [3] |
| In vivo | METHODS: Mice were intraperitoneally (ip) injected with Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) (5 mg/kg) from postnatal day (PND) 3 to 11. Pups were killed at PND12 or PND53, and brains, spleens, and livers were collected and weighed. Brain sections were stained for markers of brain injury. RESULTS Nine days after administration of Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA), mice showed a decrease in gray matter volume, white matter volume in the molecular layer of the forebrain and cerebellum, and an increase in spleen and liver weight at PND12. [1] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 16.67 mg/mL (9 mM), Sonication and heating are recommended. |
| Keywords | Pam3CSK4 TFA (112208001 free base) | Pam3CSK4 | Toll-like Receptor (TLR) | Pam-3CSK4 TFA (112208-00-1 free base) | Inhibitor | inhibit | Pam3CSK4 TFA (112208 00 1 free base) | 112208-00-1 free base | 112208-00-1 |
| Inhibitors Related | Polyinosinic-polycytidylic acid sodium | Hydroxychloroquine | Chloroquine phosphate | Hydroxychloroquine sulfate | Chloranil | Chloroquine | CU-115 | Imiquimod | TLR3-IN-1 | Resiquimod |
| Related Compound Libraries | 多肽分子库 | NO PAINS 化合物库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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