PF-06821497 NEW
| Price | $97 | $239 | $372 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: PF-06821497 | CAS No.: 1844849-10-0 |
| Purity: 97.88% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | PF-06821497 |
| Description | PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth inhibition. |
| In vitro | METHODS: U251 cells were treated with PF-06821497 (0, 50, 100 μM) and ONC201 (0, 5 μM), and cleaved PARP (clvd-PARP) and cleaved caspase 3 were analyzed by immunoblotting. RESULTS Combination treatment of PF-06821497 and ONC201 also induced more cleaved PARP in U251 cells and promoted cancer cell apoptosis. [2] |
| In vivo | METHODS: Mice bearing Karpas-422 DLBCL tumor xenografts (containing the Y641N EZH2 mutation) were treated with PF-06821497 (100,300 mg/kg, PO, twice daily) and tumor growth was observed in the mice. RESULTS Low-dose PF-06821497 can significantly inhibit tumor growth, while high-dose PF-06821497 can cause tumor regression with minimal impact on animal body weight. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (117.69 mM) |
| Keywords | PF-06821497 | PF06821497 | PF 06821497 |
| Inhibitors Related | BIX-01294 trihydrochloride | Tazemetostat | Piribedil | XY1 | UNC 0631 | GSK126 | MAK683 | EZM 2302 | EPZ015666 | AMI-1 free acid | MS37452 | MRTX-1719 |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | Histone Modification Compound Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
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