Product Details
| Product Name:
PFM03 |
CAS No.:
1558598-48-3 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | PFM03 |
| Description | PFM03 is an inhibitor of MRE11 Endonuclease that regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) [1]. |
| In vitro | PFM03, when applied at concentrations ranging from 50 to 400 μM for a duration of 30 minutes, specifically inhibits the activity of MRE11 endonuclease [1]. Furthermore, at a concentration of 100 μM over 30 minutes, PFM03 facilitates normal double-strand break (DSB) repair in G2 phase cells marked by CENPF positivity [1]. Additionally, at a dose of 50 μM for an 8-hour period, PFM03 is observed to increase the utilization of non-homologous end-joining (NHEJ) mechanisms while concurrently decreasing homologous recombination (HR) in cells [1]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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$/ |
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Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States