Pifithrin-α, p-Nitro, Cyclic NEW
| Price | $34 | $48 | $80 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Pifithrin-α, p-Nitro, Cyclic | CAS No.: 60477-38-5 |
| Purity: 99.43% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| 名称 | Pifithrin-α, p-Nitro, Cyclic |
| 描述 | Pifithrin-α, p-Nitro, Cyclic (PFN-α) is a cell-permeable, active-form inhibitor of p53. |
| 体外活性 | Pifithrin-α, p-Nitro, Cyclic (PFN-α) significantly inhibits p53-induced cell death and p21/WAF1 expression in cortical neurons exposed to etoposide, requiring concentrations an order of magnitude lower than PFT-α[1]. |
| 体内活性 | Intraocular administration of pifithrin-α at a concentration of 6 µM modestly enhances the survival of retinal ganglion cells (RGC), while it remains ineffective at 0.06 µM. Despite the observed in vitro benefits, pifithrin-α, p-Nitro, Cyclic (PFN-α) demonstrates no in vivo efficacy, even at the 6 µM concentration. Furthermore, pifithrin-α, p-Nitro, Cyclic exhibits a half-life (t1/2) of 6 hours under biological conditions[1]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 5 mg/mL (16.70 mM), Sonication is recommended. DMF : 12.5 mg/mL (41.76 mM), Sonication is recommended. |
| 关键字 | MDM-2/p53 | Inhibitor | expression | p21 | neurons | cortical | Pifithrin-a, p-Nitro, Cyclic | WAF1 | Pifithrinα, pNitro, Cyclic | Pifithrin-α, p-Nitro, Cyclic | inhibit | death | p53-triggered | PFN-alpha | posttranscriptional | cell | Pifithrin-alpha, p-Nitro, Cyclic | Pifithrin α, p Nitro, Cyclic | PFN-a |
| 相关产品 | MMRi64 | Rotenone | XI-006 | Pifithrin-μ | DPBQ | Roslin 2 bromide | BAY 1892005 | Indole-3-carbinol | Magnolol | RITA | P53R3 | CT-1 |
| 相关库 | 抗肺癌化合物库 | 铁死亡化合物库 | 经典已知活性库 | 抗癌细胞代谢库 | 细胞焦亡化合物库 | 抑制剂库 | 代谢化合物库 | 抗衰老化合物库 | 已知活性化合物库 | 转录因子库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
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