Product Details
| Product Name:
Plogosertib |
CAS No.:
1137212-79-3 |
| Purity:
99.85% |
Supply Ability:
10g |
| Release date:
2024/11/20 |
Product Introduction
Bioactivity
| Name | Plogosertib |
| Description | Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib exhibits antiproliferative and anticancer activity and can be used for the study of solid and hematologic tumors.
and hematologic tumors. |
| In vitro | In KYSE-410 cells, Plogosertib (0, 0.07, 0.15, 0.3, 0.6, 1.25 μM; 72 hours) inhibits cell proliferation in a concentration-dependent manner[2]. |
| In vivo | In the HL60 promyelocytic leukemia xenograft model, Plogosertib (40, 54, 67 mg/kg, qd 5/2/5; oral administration) inhibited tumor growth (>87%) without significant loss in body weight[2]. |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | AC010220.2HCl | AC-010220 | CYC-140 | CYC 140 | AC 010220 | AC-220 | AC010220 | AC 220 | Quizartinib dihydrochloride | Plogosertib | Quizartinib HCl | Quizartinib |
| Inhibitors Related | Onvansertib | T521 | (E/Z)-Rigosertib sodium | SBE13 Hydrochloride | Pyridoxine | Rigosertib sodium | 3MB-PP1 | Poloxin-2 | BI 2536 | GSK461364 |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States