Product Details
| Product Name:
PQR514 |
CAS No.:
1927857-55-3 |
| Purity:
99.29% |
Supply Ability:
10g |
| Release date:
2024/11/20 |
Product Introduction
Bioactivity
| Name | PQR514 |
| Description | PQR514 is a potent PI3K inhibitor with anticancer activity and inhibits cancer cell proliferation. |
| In vivo | METHODS: A single oral dose of PQR514 (10 mg/kg) was administered to male C57BL/6J mice at plasma concentrations of 4 and brain and thigh muscle concentrations were monitored over time.
RESULTS: PQR514(4) reached maximum concentrations in plasma (3282ng/mL) after 1 hour and in brain and thigh muscles after 30 minutes (1023 and 1808 ng/g, respectively).
METHODS: Using the OVCAR-3 xenograft model in BALB/c nude mice, the treatment group received PQR514 (6.3 mg/kg, p.o. QD 28 days) starting on day 17 to evaluate the in vivo anti-proliferative effect of PQR514.
RESULTS: PQR514 treatment resulted in significant anti-tumor activity, with PQR514 significantly inhibiting tumor growth compared to control mice. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Inhibitors Related | Myricetin | Erucic acid | Sapanisertib | (2S,3R,4S)-4-Hydroxyisoleucine | Duvelisib (R enantiomer) hydrochloride | Isoprenaline hydrochloride | Quercetin | Inavolisib | Quercetin Dihydrate | Apilimod |
| Related Compound Libraries | Bioactive Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States