Product Details
| Product Name:
Resomelagon |
CAS No.:
1809420-71-0 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Resomelagon |
| Description | Resomelagon (AP1189) is a potent, orally active melanocortin receptor (MR) agonist that induces Ca2+ mobilization and ERK1/2 phosphorylation, demonstrating anti-inflammatory activity useful in obesity and chronic inflammation research [1] [2]. |
| In vitro | Resomelagon (AP1189), across concentrations ranging from 0-1000 µM for an 8-minute duration in HEK293A cells, enhances melanocortin signaling by inducing ERK1/2 phosphorylation and facilitating Ca2+ mobilization. Additionally, at a concentration of 1 nM over 30 minutes in peritoneal macrophages, it exhibits anti-inflammatory properties by inhibiting the release of TNF-α and suppressing efferocytosis. Western Blot analysis confirms that in HEK293A cells, ERK1/2 phosphorylation expression escalates in a dose-dependent manner, further supporting its role in activating these cellular pathways. |
| In vivo | Resomelagon (AP1189), administered at doses ranging between 0-10 mg/kg through intraperitoneal, intravenous, and oral routes to male C57BL/6J wild-type (WT) and BALB/c mice over a period of 24 hours, effectively promotes acute inflammation resolution in vivo. At higher doses of 25-50 mg/kg, taken orally daily for 8 days, it significantly reduces arthritis symptoms in these mouse models. These effects include dose-dependent inhibition of neutrophil and monocyte infiltration and a marked reduction in arthritis symptoms, evidenced by lower clinical scores (42% decrease), reduced paw swelling (87% reduction), a lesser number of animals with all four paws affected (50% decrease), and decreased severity of inflammation (70% reduction). |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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