Product Details
| Product Name:
SC-514 |
CAS No.:
354812-17-2 |
| Purity:
99.88% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | SC-514 |
| Description | SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression. |
| In vitro | In nude mice implanted with A375 or G361 tumors, daily treatment was administered with SC-514 (25 mg/kg). |
| In vivo | In rheumatoid arthritis synovial fibroblasts (RASFs), SC-514 (100 μM) inhibits the phosphorylation and degradation of IκBα, while also preventing the translocation of p65 into the nucleus. In the presence of IL-1β-induced inflammation, SC-514 effectively suppresses the expression of NF-κB-dependent genes: IL-6 (IC50=20 μM), IL-8 (IC50=20 μM), and COX-2 (IC50=8 μM). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 40 mg/mL (178.33 mM), Sonication is recommended.
Ethanol : 2.2 mg/mL (10 mM)
|
| Keywords | IKK | I kappa B kinase | GK01140 | SC514 | SC-514 | GK-01140 | SC 514 | IκB kinase | Inhibitor | inhibit |
| Inhibitors Related | Ribociclib | Amlexanox | AEBSF hydrochloride | Resveratrol | Bakuchiol | SB 202190 | (-)-Bornyl acetate | CASIN | Palbociclib | Sodium Oxamate | Abemaciclib | Benzamidine hydrochloride |
| Related Compound Libraries | Highly Selective Inhibitor Library | Apoptosis Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Cancer Cell Differentiation Compound Library | Kinase Inhibitor Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:724708-21-8
$968.00 / 1mg
-
CAS:146032-79-3
$49.00 / 1mg
-
CAS:102649-78-5
$318.00 / 10mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$700.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-20 |
|
|
$1980.00/50mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-23 |
|
|
$1.00/1KG |
VIP5Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2024-08-15 |
United States